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个人简介
I am currently professor and investigator at the Medical Sciences Department and Institute for Research in Biomedicine (iBiMED) from the University of Aveiro. I was formerly assistant professor at the Faculty of Pharmacy and investigator at the Centre for Neuroscience and Cell Biology (CNC.IBILI), University of Coimbra. Through my scientific career I participated and lead several projects related to the establishment of cell-based tests for toxicological/pharmacological purposes and I am currently involved in the development of antitumor cell-based vaccines in collaboration with Tecnimede Pharmaceutical Group. I have an extensive expertise in cellular and molecular biology of the innate immune response, particularly the fields related to the immunobiology of dendritic cells and macrophages.
Domain of specialization: Cellular and molecular basis of the innate immune response. The immunobiology of Dendritic Cells.
Current research interests:
A- Establishment of novel immunotherapeutic approaches :
- Establishment of new dendritic cells differentiation protocols for use in oncologic and autoimmune immunotherapies.
- Strategies to potentiate cross-presentation by dendritic cells
- Strategies to increase tumor cell immunogenicity
B) Integration of danger sensing mechanisms and stress responses in innate immune cells:
- Stress pathways triggered by chemical sensitizers
- Disruption of endoplasmic reticulum (ER) homeostasis in immune cells: how can it shape the immune responses.
研究兴趣
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Ana Carolina Pinto, Patrícia Tavares,Bruno Neves, Pedro F Oliveira,Rui Vitorino,Daniel Moreira-Gonçalves,Rita Ferreira
Journal of molecular medicine (Berlin, Germany)no. 5 (2024): 617-628
Journal of the American Society for Mass Spectrometryno. 7 (2023): 1372-1382
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