基本信息
views: 0
Career Trajectory
Bio
We are interested in understanding how apicomplexan parasites initiate and regulate developmental transitions throughout their lifecycle. Our primary focus is understanding the molecular mechanisms underlying the regulation of sexual differentiation in Plasmodium falciparum.
Should I stay or should I go?
Upon invading a red blood cell, each malaria parasite is faced with a developmental “decision”: Will daughter parasites continue asexual lytic growth or instead differentiate into non-replicative sexual stages called gametocytes? This choice is of critical importance because gametocytes represent a dead end within the current host while also being the only stage able to infect blood-feeding mosquitos for transmission to the next host. Essentially, each invasion event presents individual parasites with the choice of staying in its current host or attempting transmission to the next. Striking the right persistence vs. transmission balance is critical for the parasite's survival.
How do malaria parasites decide to have sex?
Work by me and others found that the transcriptional activator AP2-G acts as a critical switch for the this differentiation decision. Using molecular biology and genetic approaches, we are currently working on understanding how AP2-G is activated and carries out its function.
Should I stay or should I go?
Upon invading a red blood cell, each malaria parasite is faced with a developmental “decision”: Will daughter parasites continue asexual lytic growth or instead differentiate into non-replicative sexual stages called gametocytes? This choice is of critical importance because gametocytes represent a dead end within the current host while also being the only stage able to infect blood-feeding mosquitos for transmission to the next host. Essentially, each invasion event presents individual parasites with the choice of staying in its current host or attempting transmission to the next. Striking the right persistence vs. transmission balance is critical for the parasite's survival.
How do malaria parasites decide to have sex?
Work by me and others found that the transcriptional activator AP2-G acts as a critical switch for the this differentiation decision. Using molecular biology and genetic approaches, we are currently working on understanding how AP2-G is activated and carries out its function.
Research Interests
Papers共 54 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Christopher R. Mansfield,Baiyi Quan,Michael E. Chirgwin, Benjamin Eduful,Philip F. Hughes,Gaëlle Neveu,Kayla Sylvester, Daniel H. Ryan,Björn F.C. Kafsack,Timothy A.J. Haystead,James W. Leahy,Michael C. Fitzgerald,
Cell Chemical Biologyno. 4 (2024): 729-742.e13
Victoria M. Schneider,Joseph E. Visone,Chantal T. Harris,Francesca Florini, Evi Hadjimichael,Xu Zhang,Mackensie R. Gross,Kyu Y. Rhee,Choukri Ben Mamoun,Bjorn F. C. Kafsack,Kirk W. Deitsch
Nature Microbiologyno. 7 (2023): 1-13
COMMUNICATIONS BIOLOGYno. 1 (2023): 1-13
biorxiv(2023)
Life Science Allianceno. 1 (2022)
biorxiv(2022)
Riward A. Campelo Morillo, Xinran Tong,Wei Xie,Steven Abel,Lindsey M. Orchard,Wassim Daher,Dinshaw J. Patel,Manuel Llinás, Karine G. Le Roch,Björn F. C. Kafsack
Nature Microbiologyno. 3 (2022): 464-464
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn