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We try to answer a fundamental biological question: what drives cancers to evolve to become resistant to treatment? Our research is dedicated to studying bladder cancer as a model disease for dissecting the fundamental biological mechanisms that drive the evolution of human cancers. We are investigating the role of the APOBEC3 mutagenic enzymes which edit the genome of cancer cells and act as evolutionary drivers of drug-resistance. We use a broad range of experimental tools and models to understand their role in cancer evolution. Our group is uniquely positioned to improve the lives of bladder cancer patients by translating our discoveries to early-phase and first-in-human clinical trials thus truly fulfilling the vision of 'bench-to-bedside and back' precision medicine.
研究兴趣
论文共 168 篇作者统计合作学者相似作者
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Shan Li,Alicia Wong,Huiyun Sun,Vipul Bhatia, Gerardo Javier,Sujata Jana,Qian Wu,Robert B. Montgomery,Jonathan L. Wright,Hung-Ming Lam,Andrew C. Hsieh,Bishoy M. Faltas,
Nature Communicationsno. 1 (2024): 1-12
EUROPEAN UROLOGYno. 3 (2024): 283-292
Cancer Researchno. 6_Supplement (2024): 337-337
JCO precision oncology (2024): e2300362-e2300362
Nature Reviews Urologyno. 7 (2023): 452-452
Kyle Rose, Andrea Necchi,Facundo Davaro,Elizabeth Davaro,Heather Huelster,Joseph Jacob,Grennady Bratslavsky,Dean Pavlick,Douglas Lin,Natalie Danzinger, Petros Grivas,Hikmat Al-Ahmadie,
JOURNAL OF UROLOGY (2023): E774-E774
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Kyle Rose, Andrea Necchi,Facundo Davaro,Elizabeth Davaro,Heather Huelster,Joseph Jacob,Grennady Bratslavsky,Dean Pavlick,Douglas Lin,Natalie Danzinger, Petros Grivas,Hikmat Al-Ahmadie,
Journal of Urologyno. Supplement 4 (2023)
JAMA NETWORK OPENno. 4 (2023): e237444-e237444
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