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个人简介
Prof. Dr. sc. Biserka Žinić (previously Kašnar, b. Bosnić)
Date and place of birth: September 25, 1952; Zagreb, Croatia
Address: Laboratory for Biomolecular Interactions and Spectroscopy, Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb,Croatia
Tel: +385 1 4561066; Fax: +385 1 4680195; E-mail: bzinic@irb.hr
Employment:
2019 – retired, External collaborator- Ruđer Bošković Institute, Division of Organic Chemistry and Biochemistry, Laboratory for biomolecular interactions and spectroscopy
2016.-2018. Senior Scientist Ruđer Bošković Institute, Laboratory for Biomolecular Interactions and Spectroscopy 2006 Senior Research Associate, Ruđer Bošković Institute, Laboratory of Supramolecular and Nucleoside Chemistry; Fields: Organic chemistry, medicinal chemistry, 2001 Research Associate; 1999 Senior Scientific Assistant; 1981 Scientific Assistant; Ruđer Bošković Institute, Laboratory of Supramolecular and Nucleoside Chemistry
Education:
1988-1991 Post-doctoral study - University of Michigan, Coll. of Pharm. Ann Arbor, USA
1988 PhD, organic chemistry, Ruđer Bošković Institute / Faculty of Science, University of Zagreb, thesis: Intramolecular Transformations of the Enantiomers in the Aliphatic Deoxyuridine Analogues Series
Main scientific interest relevant to the project:
Organic chemistry and medicinal chemistry
research experience in the synthesis of modified nuclebases, nucleosides, heterocycles, and carbohydrates; metal complexes; amino acids; fluorescent conjugates, 1,2,3-triazolo-nucleobase-amino acid derivatives
Projects:
2014.-2018. Involved in two research projects financed from The Croatian Science Foundation
a) Multifunctional molecular sensing of DNA/RNA secondary structure by chemical sensors (Head Dr. Sc. Ivo Piantanida, senior scientist, IRB); principal investigator - design and synthesis of new fluorescent derivatives of nucleobases as hybrid multifunctional chemical sensors.
b) Purine salvage pathway enzymes from Helicobacter pylori and Escherichia coli (Head Dr. Sc. Marija Luić, senior scientist, IRB); principal investigator - synthesis of new purine nucleosides or their analogues and carbohydrate compounds as potential inhibitors of PNP and ADSS enzymes
2010-present: Leader and principal investigator of chemistry - spin off company BioZyne Ltd, company for research and development in the life sciences.
2007-2013 Leader of the research project: Synthesis of novel biologically active nucleobase and nucleotide derivatives (MZOŠ 098-0982914-2935), which is part of the Program: New small molecules targeting macromolecules of tumor and inflammatory processes,
2005-2007 Leader and principal investigator - spin off company BioZyne Ltd - Preclinical evaluation of new N-sulfonylcytosine derivatives with anticancer activity.
1996-2003 Principal investigator of the scientific project: Design and synthesis of new N-sulfonylcyclourea derivatives with anticancer activity – (Herbos d.d., Sisak, Croatia and Ruđer Bošković Institute)
mentor/co-mentor: 8 PhD, 3 MSc, 2 BSc
研究兴趣
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NEW JOURNAL OF CHEMISTRYno. 37 (2023): 17434-17448
CHEMOSENSORSno. 1 (2022): 34-34
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