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Auto-immune diseases are often caused by mis-regulated innate immune responses. The recent discoveries of a collection of innate immune receptors and their downstream adaptors provided us with the unprecedented opportunities to investigate and tackle the related diseases. However, at the moment, the effort of developing related therapies is largely prohibited by a lack of knowledge of molecular information of the key components of the signaling pathways.
Based on my previous success and experience in characterizing MDA5 and RIG-I, two cellular viral RNA sensors in innate immunity, I propose to investigate their downstream adaptor protein, MAVS, and other related innate immune signaling pathways. I plan to employ a combination of biophysical, biochemical and cellular methodologies to achieve my research goals.
I encourage undergraduate and graduate students sending in enquiries about opportunities performing cutting-edge research in molecular immunology. There are also Project Officer positions available.
Auto-immune diseases are often caused by mis-regulated innate immune responses. The recent discoveries of a collection of innate immune receptors and their downstream adaptors provided us with the unprecedented opportunities to investigate and tackle the related diseases. However, at the moment, the effort of developing related therapies is largely prohibited by a lack of knowledge of molecular information of the key components of the signaling pathways.
Based on my previous success and experience in characterizing MDA5 and RIG-I, two cellular viral RNA sensors in innate immunity, I propose to investigate their downstream adaptor protein, MAVS, and other related innate immune signaling pathways. I plan to employ a combination of biophysical, biochemical and cellular methodologies to achieve my research goals.
I encourage undergraduate and graduate students sending in enquiries about opportunities performing cutting-edge research in molecular immunology. There are also Project Officer positions available.
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论文共 57 篇作者统计合作学者相似作者
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Xiangke Duan,Zhao Zhi Boo,Song Lin Chua, Kelvin Han Chung Chong,Ziqi Long,Renliang Yang, Yachun Zhou,Baptiste Janela,Sanjay Haresh Chotirmall,Florent Ginhoux,Qinghua Hu,Bin Wu,
Advanced science (Weinheim, Baden-Wurttemberg, Germany)no. 34 (2023): n/a-n/a
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Dongli Yu,Wen Song, Eddie Yong Jun Tan, Li Liu,Yu Cao,Jan Jirschitzka,Ertong Li,Elke Logemann,Chenrui Xu,Shijia Huang,Aolin Jia,Xiaoyu Chang,
Cellno. 13 (2022): 2370-2386.e18
Zhiqiang Ku,Xuping Xie,Jianqing Lin,Peng Gao,Bin Wu,Abbas El Sahili,Hang Su,Yang Liu,Xiaohua Ye, Eddie Yongjun Tan,Xin Li,Xuejun Fan,
biorxiv(2022)
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