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In her independent career, Tye began forging new discoveries surrounding DNA replication in eukaryotes, an understudied area at the time. Tye took a genetic approach to isolate mutants that regulate DNA replication which led to her identification of the minichromosome maintenance (MCM) genes in yeast in 1984. She specifically identified the MCM2, MCM3, MCM5 and MCM10 genes in yeast. Her findings together with the identification of the origin recognition complex (ORC) by Bell and Stillman in 1992 generated substantial momentum in the field of eukaryotic DNA replication.
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BIOLOGY-BASELno. 1 (2024): 13
Nature Communicationsno. 1 (2022): 1-13
Encyclopedia of Biological Chemistrypp.241-244, (2013)
Ivan Liachko,Emi Tanaka,Katherine Cox,Shau Chee Claire Chung,Lu Yang,Arael Seher,Lindsay Hallas, Eugene Cha,Gina Kang, Heather Pace, Jasmine Barrow,Maki Inada,
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