基本信息
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个人简介
Research Interests:
Hemato-oncology, normal/malignant hematopoietic stem cells,Preclinical drug discovery, Exosome in leukemogenesis, humanized(PDX)in-vivo leukemia mice models, tumour microenvironment, niche based biomarkers, Immune cells profiling and evasion mechanisms, intracellular signaling cascades, CRISPR/Cas9 and viral mediated RNA interference, PD markers and stem cell based assays for small molecules .
Selected Publications:
1. Bone Marrow Niche Trafficking of miR-126 Controls Quiescence and Self-Renewal of Hematopoietic Stem Cells in Chronic Myelogenous Leukemia. Zhang B, Nguyen LXT, Li L, Zhao D, Kumar B,... , Marcucci G. Nat Med. 2018 Mar 5. doi: 10.1038/nm.4499. PMID:29505034.
2. Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through aberrant exosome secretion. Kumar B, Garcia M, ... Bhatia R, Marcucci G, Chen CC. Leukemia. 2017 Aug 17. doi: 10.1038/leu.2017.259. PMID:28816238.
3. Antileukemic activity and cellular effects of the antimalarial agent artesunate in acute myeloid leukemia. Kumar B, Kalvala A, Chu S , Rosen S, Forman SJ, Marcucci G, Chen CC and Pullarkat V. Leuk Res. 2017 Aug;59:124-135. PMID:28646646.
4. Exosome-mediated microenvironment dysregulation in leukemia. Kumar B, Garcia M, Murakami JL, Chen CC. Biochim Biophys Acta. 2016 Mar;1863(3):464-70.PMID:26384870.
5. Altered lymphopoiesis and immunodeficiency in miR-142 null mice. Kramer NJ, Wang WL, Reyes EY, Kumar B, Chen CC, .. Taganov KD, Chau N, Boldin MP. Blood. 2015 Jun 11;125(24):3720-30. PMID: PMID:25931583.
6. 8-chloro-adenosine activity in FLT3-ITD acute myeloid leukemia. Buettner R, Nguyen LXT, Kumar B, … Marcucci G, Rosen ST. J Cell Physiol. 2019 Feb 15. doi: 10.1002/jcp.28294. PMID: 30770553.
7. The Bcl-2 inhibitor venetoclax inhibits Nrf2 antioxidant pathway activation induced by hypomethylating agents in AML. Nguyen LXT, Troadec E, Kalvala A, Kumar B… Forman SJ, Marcucci G, Pullarkat V. J Cell Physiol. 2019 Jan 8. doi: 10.1002/jcp.28091. PMID: 30623427.
8. Identification and Isolation of Mice and Human Hematopoietic Stem Cells. Kumar B, Madabushi SS. Methods Mol Biol. 2018;1842:55-68. PMID:30196401.
9. Acute myeloid leukemia remodels endosteal vascular niche into a leukemic niche. Kumar B, Chen CC. Stem Cell Investig. 2018 Oct 16;5:34. PMID: 30498745.
10. Identification of a CD133-CD55- population functions as a fetal common skeletal progenitor. Weng L, Hu X, Kumar B, Garcia M, Marcucci G, Forman SJ, and Chen CC. Nature Scientific reports., 2016 Dec 8;6:38632.
11. Identification of a common mesenchymal stromal progenitor for the adult hematopoietic niche. Hu X, Garcia M, Weng L, Jung X, Murakami J, Kumar B, Warden C, Todorov C, and Chen CC. Nature communications 2016 Oct 10;7:13095 | DOI: 10.1038/ncomm.PMID:27721421.
12. Central nervous system involvement at second relapse in acute promyelocytic leukemia treated with ATRA and chemotherapy. Kumar B, Sharma V, Chopra A, Mahapatra M, Kumar R, Mathur S, Sazawal S, Kumar S, Saxena R. Leuk Res. 2010 Oct;34(10). PMID:20537387.
13. Haematological & molecular profile of acute myelogenous leukaemia in India. Sazawal S, Kumar B, Hasan SK, Dutta P, Kumar R, Chaubey R, Mir R, Saxena R. Indian J Med Res. 2009 Mar;129(3):256-61.PMID:19491417.
14. Glutathione S-transferase gene deletions and their effect on iron status in HbE/beta thalassemia patients. Sharma V, Kumar B, Saxena R. Ann Hematol. 2010 Apr;89(4):411-4. PMID:19838709.
15. Alpha globin gene numbers: an important modifier of HbE/beta thalassemia. Sharma V, Kumar B, Kumar G, Saxena R. Hematology. 2009 Oct;14(5):297-300. PMID:19843387.
16. Childhood CML in India: b2a2 transcript is more common than b3a2. Hasan SK, Sazawal S, Kumar B, Chaubey R, Mishra P, Mir R, Chaudhry VP, Saxena R. Cancer Genet Cytogenet. 2006 Aug;169(1):76-7. PMID:16875942.
17. Impact of FLT3 internal tandem duplications on Indian acute promyelocytic leukemia patients: prognostic implications. Hasan SK, Sazawal S, Dutta P, Pillai LS, Kumar B, Chaubey R, Kumar R, Saxena R. Hematology. 2007 Apr;12(2):99-101. PMID:17454189.
18. Timing of allogeneic BMT for CML patients in India: does it affect response? Sazawal S, Hasan SK, Kumar B, Kumar R, Kumar L, Saxena R. American Journal of Hematology 2007 Apr;82(4):329. PMID:16947319.
19. Over-representation of bcr3 subtype of PML/RARalpha fusion gene in APL in Indian patients. Sazawal S, Hasan SK, Dutta P, Kumar B, Kumar R, Kumar L, Choudhry VP, Saxena R. Annals of Hematol. 2005 Nov;84(12):781-4. PMID:16132910.
研究兴趣
论文共 59 篇作者统计合作学者相似作者
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Mario L. Marques-Piubelli,Bijender Kumar,Rafet Basar,Siler Panowski,Surabhi Srinivasan, Kevin Norwood,Sacha Prashad,Victoria Szenes,Arun Balakumaran, Akanksha Arandhya,Wei Lu,Khaja Khan,
Virchows Archivpp.1-5, (2024)
Leukemiano. 1 (2024): 82-95
Luciana Melo Garcia, Achintyan Gangadharan,Pinaki Banerjee,Paul Lin,May Daher,Hind Rafei,Bijender Kumar,Katayoun Rezvani
BLOOD (2023): 4809
Irene Ganan-Gomez,Bijender Kumar,Juan Jose Rodriguez Sevilla,Feiyang Ma,Yi June Kim,Kelly S. Chien, Kate Nelson, Hui Yang, Roselyn Tan,Zongrui Li,Tomoyuki Tanaka,Hidetaka Uryu,
BLOOD (2023): 514
G. S. Manzar,H. Rafei,B. Kumar,M. Shanley,S. Acharya, B. Liu, A. Xu, X. A. Wang, S. Islam,M. Kaplan,R. Basar, N. Uprety,
International journal of radiation oncology, biology, physicsno. 2 (2023): S167-S168
crossref(2023)
crossref(2023)
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作者统计
#Papers: 59
#Citation: 731
H-Index: 15
G-Index: 26
Sociability: 6
Diversity: 2
Activity: 8
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