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Research Interest
There is a pressing need for new therapeutic strategies to address the epidemic of obesity and its co-morbidities. Bariatric surgery, a surgical manipulation of the gut for weight loss, causes remarkable improvements in obesity and several of its co-morbidities. Specifically, bariatric surgery causes remission of type 2 diabetes (T2DM) and cardiovascular diseases (CVD) such as hypertension. Bariatric surgery also substantially decreases the risk of cancer. Importantly, the metabolic benefits of bariatric surgery often occur prior to weight loss, suggesting that mechanisms other than body weight contribute. Identification of the mechanisms underlying these surgically-induced benefits will provide insight into the basic biology by which the gut regulates whole body physiology, leading to the development of novel therapies for managing obesity and its co-morbidities. Thus, the overall theme of our research program is identifying the mechanisms by which bariatric surgery causes these health benefits using animal models of bariatric surgery. The primary mechanisms of interest in our lab are glucagon-like peptide-1 (GLP-1) and bile acid signaling.
There is a pressing need for new therapeutic strategies to address the epidemic of obesity and its co-morbidities. Bariatric surgery, a surgical manipulation of the gut for weight loss, causes remarkable improvements in obesity and several of its co-morbidities. Specifically, bariatric surgery causes remission of type 2 diabetes (T2DM) and cardiovascular diseases (CVD) such as hypertension. Bariatric surgery also substantially decreases the risk of cancer. Importantly, the metabolic benefits of bariatric surgery often occur prior to weight loss, suggesting that mechanisms other than body weight contribute. Identification of the mechanisms underlying these surgically-induced benefits will provide insight into the basic biology by which the gut regulates whole body physiology, leading to the development of novel therapies for managing obesity and its co-morbidities. Thus, the overall theme of our research program is identifying the mechanisms by which bariatric surgery causes these health benefits using animal models of bariatric surgery. The primary mechanisms of interest in our lab are glucagon-like peptide-1 (GLP-1) and bile acid signaling.
Research Interests
Papers共 100 篇Author StatisticsCo-AuthorSimilar Experts
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Melanie A. Reuter, Madelynn Tucker,Zara Marfori,Rahaf Shishani,Jessica Miranda Bustamante, Rosalinda Moreno,Michael L. Goodson,Allison Ehrlich,Ameer Y. Taha,Pamela J. Lein,Nikhil Joshi,Ilana Brito,
GUT MICROBESno. 1 (2024): 2315632-2315632
Obesity Surgeryno. 7 (2024): 1-9
PloS oneno. 5 (2024): e0303110-e0303110
Michael Merkhassine,Reilly W Coch,Carol E Frederick, Lucinda L Bennett,Seth A Peng, Benjamin Morse,Bethany P Cummings,John P Loftus
The Journal of endocrinologyno. 2 (2024)
Hisham Hussan,Mohamed R. Ali, Victoria Lyo,Amy Webb, Maciej Pietrzak,Jiangjiang Zhu,Fouad Choueiry, Hong Li,Bethany P. Cummings,Maria L. Marco,Valentina Medici,Steven K. Clinton
Obesity Surgerypp.1-14, (2024)
PLOS ONEno. 5 (2024)
Proceedings of the National Academy of Sciences of the United States of Americano. 28 (2024): e2318691121-e2318691121
Diabetesno. 8 (2023): 1045-1054
bioRxiv : the preprint server for biologyno. 28 (2023): e2318691121-e2318691121
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Author Statistics
#Papers: 97
#Citation: 2285
H-Index: 27
G-Index: 47
Sociability: 6
Diversity: 0
Activity: 1
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