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个人简介
O’Malley's work has been on the primary actions of steroid hormones and nuclear receptors. Bert elucidated the overall genetic transcriptional pathway of steroid and intracellular hormone action, discovered nuclear receptor(NR) coactivators (CoAs), discovered the functional 3-D structures CoA-NR complexes on DNA, and the critical roles for coactivators in physiology and diseases. He has published over 700 papers and holds 29 patents in the fields of gene regulation, molecular endocrinology and steroid receptors and transcriptional coactivators. His work on molecular mechanisms of steroid receptor coactivators has great relevance to genetic and reproductive diseases, disorders of metabolism and diabetes, myocardial infarct induced heart failure, and especially, cancers. He is considered as the 'father of molecular endocrinology' and has received over 65 national/international awards/prizes for his scientific achievements in this field.
研究兴趣
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Proceedings of the National Academy of Sciences of the United States of Americano. 20 (2023)
Elsevier eBookspp.373-380, (2023)
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bioRxiv the preprint server for biologyno. 23 (2023)
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