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Platelets are critical regulators of vascular integrity. Vessel wall injury triggers sudden platelet activation and platelet plug formation, followed by coagulant activity and the formation of fibrin-containing thrombi which occlude the site of injury. These events are crucial to limit blood loss at sites of tissue trauma but may also block diseased vessels leading to ischemia and infarction of vital organs. Besides these well-established functions, platelets are increasingly recognized for their critical role in processes, such as inflammation, wound healing and tumorigenesis. One major objective of our research therefore is to understand the role of platelet membrane glycoproteins and their signaling pathways in normal hemostasis, thrombotic and thrombo-inflammatory diseases, as well as in cancer. Furthermore, we investigate the mechanisms underlying platelet biogenesis under both physiological and pathological conditions, mainly by focusing on cytoskeletal components and their regulators.
We use genetically modified mouse strains with defined defects in platelet receptors or signaling molecules to study the processes of platelet formation, adhesion and activation in vitro and in vivo. Our experiments serve as a basis for the development of antibody-based antithrombotic therapies which are then evaluated in murine models of arterial thrombosis and systemic inflammation.
We use genetically modified mouse strains with defined defects in platelet receptors or signaling molecules to study the processes of platelet formation, adhesion and activation in vitro and in vivo. Our experiments serve as a basis for the development of antibody-based antithrombotic therapies which are then evaluated in murine models of arterial thrombosis and systemic inflammation.
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Papers共 510 篇Author StatisticsCo-AuthorSimilar Experts
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Martina Derler, Theresa Teubenbacher, Anna Carapuig,Bernhard Nieswandt,Johannes Fessler,Dagmar Kolb,Marion Mussbacher
JOURNAL OF THROMBOSIS AND HAEMOSTASISno. 5 (2024): 1475-1488
Johannes Herrmann,Lukas J Weiss, Bastian Just,Kristina Mott,Maria Drayss, Judith Kleiss,Jonathan Riesner, Quirin Notz,Daniel Röder,Rainer Leyh,Sarah Beck, Dirk Weismann,
Journal of thrombosis and haemostasis : JTH (2024)
Journal of Thrombosis and Haemostasis (2024)
Philine Wegner,Julia Drube, Lisa Ziegler,Birgit Strotmann, Raphaela Marquardt,Claudia Kuechler,Marco Groth,Bernhard Nieswandt,Nico Andreas,Sebastian Drube
IMMUNOLOGYno. 1 (2024): 61-76
Peter Seizer,Saskia N. von Ungern-Sternberg, Verena Haug,Valerie Dicenta,Annabelle Rosa,Elke Butt, Moritz Noethel,Anne-Katrin Rohlfing,Manuel Sigle,Peter P. Nawroth,Claudia Nussbaum, Markus Sperandio,
CARDIOVASCULAR RESEARCHno. 4 (2024): 385-402
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2024)
Ophélie Le Chapelain,Soumaya Jadoui,Angèle Gros, Samir Barbaria, Keltouma Benmeziane,Véronique Ollivier,Sébastien Dupont,Mialitiana Solo Nomenjanahary, Sabrina Mavouna, Jasmina Rogozarski,Marie-Anne Mawhin,Giuseppina Caligiuri,
Nature Cardiovascular Researchno. 4 (2023): 1-15
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