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Bio
Our research focuses on mechanisms underlying the regulation of gene expression and how these mechanisms are disrupted in human diseases and disorders. Most of our research is directed at understanding how alternative splicing is regulated and integrated with other layers of gene expression to control fundamental biological processes. For example, we have discovered alternative splicing "switches" with critical roles in the regulation of transcriptional programs required for neural and embryonic stem cell fate. More recently, we have discovered and characterized a highly conserved alternative splicing regulatory network comprising 3-27 nt neuronal microexons, and have provided evidence that the disruption of this network represents a common mechanism underlying autism spectrum disorders.
Research Interests
Papers共 245 篇Author StatisticsCo-AuthorSimilar Experts
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biorxiv(2024)
PLOS PATHOGENSno. 4 (2024)
Syed Nabeel-Shah,Shuye Pu,Giovanni L. Burke,Nujhat Ahmed,Ulrich Braunschweig, Shaghayegh Farhangmehr, Hyunmin Lee,Mingkun Wu,Zuyao Ni, Hua Tang,Guoqing Zhong,Edyta Marcon,
crossref(2024)
biorxiv(2024)
Nature cell biologyno. 4 (2023): 592-603
Debashish Ray,Kaitlin U. Laverty,Arttu Jolma,Kate Nie,Reuben Samson,Sara E. Pour, Cyrus L. Tam, Niklas von Krosigk,Syed Nabeel-Shah,Mihai Albu, Hong Zheng,Gabrielle Perron,
Scientific Reportsno. 1 (2023): 1-15
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