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职业迁徙
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Research in our group combines experimental lineage tracing strategies and single-cell methods with concepts from non-equilibrium statistical physics and mathematics to address the fate behaviour of stem and progenitor cells in the development, maintenance and regeneration of tissues, and factors leading to their dysregulation in diseased states. In particular, we have resolved strategies of stem cell self-renewal in the maintenance of epithelial tissues, including mammalian brain, epidermis, intestine, lung and testis.
Our studies have emphasized the role of stochastic renewal programmes in the regulation of stem cell fate, questioning the nature of stem cell identity and function. We have extended these approaches to study the development and patterning of adult tissues, including the eye, heart, mammary epithelium, pancreas and skin epidermis. At the same, we are collaborating with partner labs to address the cellular basis of tumour initiation. In particular, we are interested in understanding how mechanisms of natural injury-induced cellular reprogramming become subverted during the early stages of tumour development, with ongoing studies in tissues of the gastrointestinal tract, lung, and the brain.
Going forward, the group is placing increasing emphasis on the study of developmental programmes in human epithelia, making use of advances in stem cell-derived 3D organ culture models.
Our studies have emphasized the role of stochastic renewal programmes in the regulation of stem cell fate, questioning the nature of stem cell identity and function. We have extended these approaches to study the development and patterning of adult tissues, including the eye, heart, mammary epithelium, pancreas and skin epidermis. At the same, we are collaborating with partner labs to address the cellular basis of tumour initiation. In particular, we are interested in understanding how mechanisms of natural injury-induced cellular reprogramming become subverted during the early stages of tumour development, with ongoing studies in tissues of the gastrointestinal tract, lung, and the brain.
Going forward, the group is placing increasing emphasis on the study of developmental programmes in human epithelia, making use of advances in stem cell-derived 3D organ culture models.
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biorxiv(2024)
Batoul Farhat,Ignacio Bordeu,Bernd Jagla, Stephanie Ibrahim,Emmanuel Beaurepaire,Sonia Stefanovic,Jean Livet, Hugo Blanc,Karine Loulier,Benjamin D. Simons,Michel Puceat
DEVELOPMENTAL CELLno. 3 (2024): 339-350.e4
Szu-Hsien Sam Wu,Somi Kim,Heetak Lee,Ji-Hyun Lee, So-Yeon Park,Réka Bakonyi,Isaree Teriyapirom,Natalia Hallay, Sandra Pilat-Carotta,Hans-Christian Theussl,Jihoon Kim,Joo-Hyeon Lee,
Nature Communicationsno. 1 (2023): 1-11
Nature reviews. Cancerno. 10 (2023): 710-724
Yicheng Wu,Sara Bottes, Roberto Fisch, Cinzia Zehnder,John Darby Cole,Gregor-Alexander Pilz,Fritjof Helmchen,Benjamin D. Simons,Sebastian Jessberger
Nature Agingno. 4 (2023): 380-390
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