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Our research group aims to understand the roles that proteins play in human physiological and pathological processes and to use this knowledge to identify novel therapeutic targets and drugs to treat disease. To achieve these goals, we develop and apply new technologies that bridge the fields of chemistry and biology, ascribing to the philosophy that the most significant biomedical problems require creative multidisciplinary approaches for their solution. Our technological innovations address fundamental challenges in human physiology and disease that are beyond the scope of contemporary methods. For instance, enzymes are tightly regulated by post-translational events in vivo, meaning that their activity may not correlate with expression as measured by standard genomic and proteomic approaches. Considering that it is an enzyme's activity, rather than abundance that ultimately dictates its role in cell physiology and pathology, we have introduced a set of proteomic technologies that directly measures this parameter. These activity-based protein profiling (ABPP) methods exploit the power of chemistry to engender new tools and assays for the global analysis of enzyme activities. The enzyme activity profiles generated by ABPP constitute unique molecular portraits of cells and tissues that illuminate how metabolic and signaling networks are regulated in vivo. Additionally, by evaluating enzymes based on functional properties rather than mere abundance, ABPP acquires high-content proteomic information that is enriched in novel markers and targets for the diagnosis and treatment of human disease. We have also shown that ABPP can serve as a near-universal assay for the discovery of small-molecule inhibitors or ligands of proteins directly in native biological systems and, through doing so, greatly expand the scope of proteins that can be targeted by chemical probes and drugs.
研究兴趣
论文共 794 篇作者统计合作学者相似作者
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Zhonglin Liu,Jarrett R. Remsberg,Haoxin Li,Evert Njomen, Kristen E. DeMeester,Yongfeng Tao,Guoqin Xia, Rachel E. Hayward, Minjin Yoo, Tracey Nguyen,Gabriel M. Simon,Stuart L. Schreiber,
Journal of the American Chemical Society (2024)
Daisuke Ogasawara,David B Konrad,Zher Yin Tan, Kimberly L Carey, Jessica Luo, Sang Joon Won,Haoxin Li, Trever Carter, Kristen E DeMeester,Evert Njomen,Stuart L Schreiber,Ramnik J Xavier,
bioRxiv : the preprint server for biology (2024)
Yuanjin Zhang, Zhonglin Liu, Marsha Hirschi,Oleg Brodsky, Eric Johnson, Sang Joon Won,Asako Nagata, Matthew D Petroski,Jaimeen D Majmudar, Sherry Niessen,Todd VanArsdale,Adam M Gilbert,
bioRxiv : the preprint server for biology (2024)
Isaac O Akefe,Saber H Saber,Benjamin Matthews, Bharat G Venkatesh,Rachel S Gormal,Daniel G Blackmore,Suzy Alexander, Emma Sieriecki,Yann Gambin, Jesus Bertran-Gonzalez, Nicolas Vitale, Yann Humeau,
The EMBO journalno. 4 (2024): 533-567
Cancer Researchno. 6_Supplement (2024): 1655-1655
Sang Joon Won,Yuxiang Zhang, Christopher J Reinhardt, Nicole S MacRae, Kristen E DeMeester,Evert Njomen, Lauren M Hargis,Jarrett R Remsberg,Bruno Melillo,Benjamin F Cravatt,Michael A Erb
bioRxiv : the preprint server for biology (2024)
Caroline Stanton, Jie Sun,Kayla Nutsch,Jessica D. Rosarda,Thu Nguyen, Chloris Li-Ma, Evert Njomen,Bruno Melillo,Sergei Kutseikin,Enrique Saez,Benjamin F. Cravatt,John R. Teijaro,
ISRAEL JOURNAL OF CHEMISTRY (2023)
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British journal of pharmacologyno. 24 (2023): 3130-3145
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