We are interested in how persistent inflammation in the brain influences neurocognitive function in people with HIV/AIDS. Our current emphasis is on its effect on synaptic protein turnover and dopaminergic synaptic transmission. We are a national resource for HIV/AIDS neuropathology and a founding center of the National NeuroAIDS Tissue Consortium. We also participate in the CHARTER study, which is a multi-site cross-sectional and longitudinal study of dementia in HIV-infected people.