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The longest standing goal of my lab has been to understand how particular proteins direct accurate chromosome segregation at mitosis and meiosis. In humans, the chromosomal element—the centromere—that directs this process is not defined by a particular DNA sequence. Rather, the location of the centromere is dictated by an epigenetic mark generated by one or more resident proteins. These centromeric proteins interact directly with the DNA to create a specialized chromatin compartment that is distinct from any other part of the chromosome. By taking biophysical, biochemical, genetic, epigenomic, and cell biological approaches, our work is to define the composition and physical characteristics of the protein and protein/DNA complexes that epigenetically mark the location of the centromere on the chromosome. This work involves building centromeric chromatin from its component parts for analysis of its physical characteristics
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论文共 58 篇作者统计合作学者相似作者
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Craig W Gambogi, Gabriel J Birchak, Elie Mer, David M Brown,George Yankson,Kathryn Kixmoeller,Janardan N Gavade, Josh L Espinoza, Prakriti Kashyap, Chris L Dupont, Glennis A Logsdon,Patrick Heun,
ELIFE (2024)
Uday Kiran Velagapudi, Elise Rouleau-Turcotte,Ramya Billur,Xuwei Shao, Manisha Patil,Ben E. Black,John M. Pascal,Tanaji T. Talele
Nature Communicationsno. 1 (2024): 1-12
bioRxiv : the preprint server for biology (2024)
crossref(2024)
Methods in molecular biology (Clifton, N.J.) (2023): 211-248
SCIENCE ADVANCESno. 46 (2023): 940-940
bioRxiv : the preprint server for biology (2023)
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