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Bio
Protein transport across bacterial cell membranes
We study the molecular machines involved in forming the bacteria cell envelope, with a special emphasis on those machines that transport macromolecules across the cell membranes. These nanomachines have crucial roles in pathogenesis, motility, and antibiotic resistance, and are amongst the most mechanistically interesting proteins in the cell. The most established systems under study in our laboratory are:
The Tat (twin-arginine translocation) protein transport system which exports folded proteins across the bacterial inner membrane. The Tat system is involved in a wide range of fundamental cellular processes in bacteria and is essential for the virulence of bacterial pathogens. The mechanism of Tat transport is radically different from that employed by other protein transporters, enabling it to translocate folded proteins without compromising the ion permeability barrier of the membrane.
The Type IX secretion system (T9SS) which is involved in severe dental disease and in bacterial gliding motility. This multi-component system exports proteins through a huge pore in the outer membrane using the energy of the inner membrane proton electrochemical gradient.
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JOURNAL OF MOLECULAR BIOLOGYno. 2 (2024): 168368-168368
Nature Microbiologyno. 4 (2024): 1-14
Ben C. Berks,Frédéric Lauber,Justin C. Deme,Xiaolong Liu, Andreas Kjær, Helen Miller,Felicity Alcock,Susan M. Lea
Research Square (Research Square) (2023)
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