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Vision in animals is triggered via absorption of a photon by a visual pigment located in the photoreceptors of the eye, resulting in a signal to the brain that light has been perceived. Changes in the functional properties of visual pigments can therefore have profound consequences on the visual capabilities of an organism. The visual system has a surprisingly large dynamic range, and is highly specialized for the efficient sensing of light even under very low light levels. How is this achieved at the molecular level? We are also interested in mechanisms of spectral tuning, and the evolution of color vision. We study these and other questions by reconstructing the evolutionary history of visual pigments, so that important changes in their function can be examined experimentally. This involves using computational tools to infer ancestral pigment sequences, followed by synthesis and expression of the ancestral genes in the laboratory so that their biochemical properties can be assayed directly. We compare reconstructed ancestors with present day visual pigments, particularly those from animals that live in unusual visual environments. Our research uses a variety of interdiscplinary approaches to better understand the evolution of visual pigment structure and function, including next generation sequencing, computational sequence analysis, site-directed mutagenesis and protein expression.
Vision in animals is triggered via absorption of a photon by a visual pigment located in the photoreceptors of the eye, resulting in a signal to the brain that light has been perceived. Changes in the functional properties of visual pigments can therefore have profound consequences on the visual capabilities of an organism. The visual system has a surprisingly large dynamic range, and is highly specialized for the efficient sensing of light even under very low light levels. How is this achieved at the molecular level? We are also interested in mechanisms of spectral tuning, and the evolution of color vision. We study these and other questions by reconstructing the evolutionary history of visual pigments, so that important changes in their function can be examined experimentally. This involves using computational tools to infer ancestral pigment sequences, followed by synthesis and expression of the ancestral genes in the laboratory so that their biochemical properties can be assayed directly. We compare reconstructed ancestors with present day visual pigments, particularly those from animals that live in unusual visual environments. Our research uses a variety of interdiscplinary approaches to better understand the evolution of visual pigment structure and function, including next generation sequencing, computational sequence analysis, site-directed mutagenesis and protein expression.
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Ahmed A Elbassiouny,Leslie T Buck, Luis E Abatti,Jennifer A Mitchell, William G R Crampton, Nathan R Lovejoy,Belinda S W Chang
The Journal of biological chemistryno. 3 (2024): 105727-105727
Alexander Van Nynatten, Alexander T. Duncan, Ryan Lauzon, Tom A. Sheldon, Steven K. Chen,Nathan R. Lovejoy, Nicholas E. Mandrak,Belinda S. W. Chang
Katherine D Chau,Frances E Hauser,Alexander Van Nynatten, Jacob M Daane,Matthew P Harris,Belinda S W Chang,Nathan R Lovejoy
Journal of molecular evolutionno. 2 (2024): 93-103
Gianni M Castiglione, Yan L I Chiu,Eduardo de A Gutierrez,Alexander Van Nynatten,Frances E Hauser, Matthew Preston,Nihar Bhattacharyya,Ryan K Schott,Belinda S W Chang
Current biology : CBno. 21 (2023): 4733-4740.e4
Einat Hauzman,Michele E. R. Pierotti,Nihar Bhattacharyya,Juliana H. Tashiro,Carola A. M. Yovanovich, Pollyanna Fernandes Campos,Dora Fix Ventura,Belinda S. W. Chang
Social Science Research Network (2020)
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