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Spinal cord injury (SCI) is a devastating condition that results in permanent functional impairments. The goal of Dr. D. Michele Basso’s research is to develop rehabilitative therapies that promote recovery of mobility. The unique experience is working on the brink of translation and interacting closely with the OSU NeuroRecovery Network (NRN) clinic for human SCI which she directs. This clinic uses treadmill training to promote recovery after chronic, incomplete SCI and we examine the rate and extent of change in function and quality of life. Recovery of locomotion is complex because it depends on reducing cellular cascades that inhibit learning while at the same time promoting robust neural plasticity. In addition, neuropathic pain can develop after SCI and interfere with recovery. It is her belief that the optimal therapeutic outcome will result from a treatment that is tailored to the severity of neuropathology, the time of intervention and the specificity of the training task. Cellular factors such as inflammation and matrix biology at the synapse may directly influence the receptivity to training. We combine behavioral, cellular, and physiological assessments and take a systems approach to answer these questions. To accurately characterize the type and extent of restitution of function, we also develop new assessment tools which quantify motor and sensory recovery in animals and humans with SCI.
Spinal cord injury (SCI) is a devastating condition that results in permanent functional impairments. The goal of Dr. D. Michele Basso’s research is to develop rehabilitative therapies that promote recovery of mobility. The unique experience is working on the brink of translation and interacting closely with the OSU NeuroRecovery Network (NRN) clinic for human SCI which she directs. This clinic uses treadmill training to promote recovery after chronic, incomplete SCI and we examine the rate and extent of change in function and quality of life. Recovery of locomotion is complex because it depends on reducing cellular cascades that inhibit learning while at the same time promoting robust neural plasticity. In addition, neuropathic pain can develop after SCI and interfere with recovery. It is her belief that the optimal therapeutic outcome will result from a treatment that is tailored to the severity of neuropathology, the time of intervention and the specificity of the training task. Cellular factors such as inflammation and matrix biology at the synapse may directly influence the receptivity to training. We combine behavioral, cellular, and physiological assessments and take a systems approach to answer these questions. To accurately characterize the type and extent of restitution of function, we also develop new assessment tools which quantify motor and sensory recovery in animals and humans with SCI.
研究兴趣
论文共 105 篇作者统计合作学者相似作者
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Experimental neurology (2021): 113853-113853
medRxiv (Cold Spring Harbor Laboratory) (2020)
Experimental neurology (2020): 113410-113410
Journal of Clinical and Translational Scienceno. S1 (2018): 29-29
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作者统计
#Papers: 107
#Citation: 14239
H-Index: 37
G-Index: 88
Sociability: 6
Diversity: 3
Activity: 1
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