基本信息
views: 46
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Baruch’s research did not stop with the cloning of the transporters, the cloning just gave him the tools to continue with his passion, i.e. to figure out how these transporters work. In consequence, a large number of papers were published with diligent structure function analysis of GABA and glutamate transporter. His publications are too numerous to discuss, with a total number of 139 papers, showcasing a very prolific career. However, two additional major contributions should be highlighted: (1) The identification of the chloride binding site of the GABA transporter, published in Nature in 2007. This breakthrough was possible because of Baruch's keen eye in identifying minor differences in sequences of GAT1 (SLC6) family members, which, in combination with careful site-directed mutagenesis approaches allowed the prediction of this important binding site. (2) The discovery of the inverted repeat structural fold of glutamate transporters, in collaboration with Lucy Forrest, which led to the prediction of an inward facing structure of the transporter. This structure was soon after confirmed by x-ray crystallography with GltPh.
Research Interests
Papers共 134 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Erika Lazzarin,Ralph Gradisch, Sophie M.C. Skopec,Leticia Alves da Silva, Chiara Sebastianelli-Schoditsch,Dániel Szöllősi,Julian Maier,Sonja Sucic,Marko Roblek,Baruch I. Kanner,Harald H. Sitte,Thomas Stockner
bioRxiv (Cold Spring Harbor Laboratory) (2024)
Smruti Ranjan Nayak,Deepthi Joseph,Georg Höfner,Archishman Dakua,Arunabh Athreya,Klaus T. Wanner,Baruch I. Kanner,Aravind Penmatsa
Nature structural & molecular biologyno. 7 (2023): 1023-1032
crossref(2021)
Epilepsiano. 9 (2018): 135-141
Cited0Views0Bibtex
0
0
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn