基本信息
views: 309
Career Trajectory
Bio
Over my career, my clinical and investigational work has focused on the treatment of heart and lung end-stage diseases. I have approached that task by combining heart and lung transplantation with the developments in total artificial heart, ventricular assist devices, ECMO, and now ambulatory ECMO. To do so, I established the McGowan Center for Artificial Organ Development at the University of Pittsburgh, which was a $10 million philanthropic effort resulting in the multi-use free-standing facility. I have continued my investigative work and, since 1986, have been continuously funded as a principal investigator by the NIH. Work continued in an ambulatory artificial lung, which first was funded in 1990, and has used more than $20 million of NIH support. The device once imagined on a napkin is now cleared by the FDA for clinical use, and the role-out of the Breethe system designed for home use will begin in the next few months. The work on this system evolved with clinical input from experiences in patients with end-stage respiratory distress but also included multi-disciplinary input from a broad array of experts in the bioengineering aspects of the project. Recently, my funding has extended to include clinical program director for xenotransplantation of the heart. This program’s ongoing focus has been the outcome in genetically engineered swine hearts when placed in baboons. Success with that program (survivals in excess of 150 days and ongoing) suggests that clinical implementation may be appropriate soon. Throughout my career I have been a mentor of cardiothoracic surgical trainees and other post doc engineers.
Research Interests
Papers共 1097 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Oneib Khan,Mahdokht Parsirad,Bartley Griffith, Ubaid Khan,Justin Brilliant, Andrew Tully, Javier Galindo,Manjula Ananthram,Susie Hong-Zohlman,Alison Grazioli,Richard Amara,Stephen R. Shorofsky,
Heart Rhythmno. 5 (2024): S282-S283
The Journal of thoracic and cardiovascular surgery (2024)
Heart Rhythmno. 5 (2024): S279
Journal of the American College of Cardiologyno. 13 (2024): 1574
Physiological reviewsno. 3 (2024): 1409-1459
Journal of the American College of Cardiologyno. 13 (2024): 1489
Journal of the American College of Cardiologyno. 13 (2024): 222
Oneib Khan,Justin Brilliant,Bartley Griffith,Mahdokht Parsirad, Ubaid Khan, Andrew Tully, Javier Galindo,Manjula Ananthram,Susie Hong-Zohlman,Alison Grazioli,Richard Amara,Stephen R. Shorofsky,
Heart Rhythmno. 5 (2024): S613-S614
The Journal of Thoracic and Cardiovascular Surgery (2024)
Load More
Author Statistics
#Papers: 1093
#Citation: 42601
H-Index: 102
G-Index: 165
Sociability: 8
Diversity: 1
Activity: 4
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn