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An important component of his research program is focused on understanding the consequences of intrauterine exposure to drugs of abuse. He has pursued studies in animals (mice) and humans to identify basic mechanisms underlying alterations in brain development resulting from gestational exposure to cocaine, their interaction with genetic factors, and their impact on learning and behavior. This work has included the application of computer-based methods for morphometric analyses of the MR scans of infants and children following intrauterine exposure to drugs of abuse. His approach is to use such sophisticated imaging methods as a foil for bi-directional translational research, which he has additionally applied to the fields of gene therapy for neurogenetic disorders, autism, and traumatic brain injury.
The current focus of his research is identifying biomarkers predictive of ongoing symptoms following traumatic brain injury. That effort now includes the use of visual tracking, structural brain imaging, and functional assessments of vision, balance, and exercise tolerance as a means of elucidating the specific consequences of traumatic brain injury, as a starting point for individualizing therapy for individuals with ongoing post-concussive symptoms. Most recently this has included a study to identify the benefit of a graded exercise program for individuals unable to return to their baseline level of mental and physical functioning following mild traumatic brain injury.
The current focus of his research is identifying biomarkers predictive of ongoing symptoms following traumatic brain injury. That effort now includes the use of visual tracking, structural brain imaging, and functional assessments of vision, balance, and exercise tolerance as a means of elucidating the specific consequences of traumatic brain injury, as a starting point for individualizing therapy for individuals with ongoing post-concussive symptoms. Most recently this has included a study to identify the benefit of a graded exercise program for individuals unable to return to their baseline level of mental and physical functioning following mild traumatic brain injury.
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The Lancet. Child & adolescent healthno. 8 (2018): 582-590
Moran Hausman-Kedem,Barry E. Kosofsky,Gail Ross,Kaleb Yohay, Emily Forrest, Margaret H. Dennin, Reena Patel, Kristen Bennett, James P. Holahan,Mary J. Ward
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