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My primary research is concerned with developing abiotic and biotic stress resistance in plants using genetic engineering strategies. My principal approach involves GABA (gamma-aminobutyrate), a ubiquitous 4-C, non-protein amino acid of uncertain function in plants. However, it does accumulate in response to a variety of abiotic and biotic stresses, including temperature and oxygen shock, as well as insect damage. We are continuing to identify the proteins involved in GABA metabolism and transport, and their corresponding genes, using state-of-the- art analytical tools and biochemical and molecular techniques. These genes are typically being expressed in recombinant expression systems, with the recombinant proteins being isolated and purified for biochemical and physical characterization. The genes are also being modified and reinserted by Agrobacterium-mediated transformation or particle bombardment. We are using various Arabidopsis mutants (overexpression, knockout, knockdown) to elucidate the physiological function and regulation of GABA metabolism, and the interactions among GABA metabolism, photorespiration, polyamines and the tricarboxylic acid cycle. Also, we are investigating the role of GABA in the onset of physiological disorders in tree fruit stored under controlled atmosphere conditions. In addition to manipulating GABA metabolism, we are collaborating in studies of N use efficiency and carotenoid metabolism.
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CANADIAN JOURNAL OF PLANT SCIENCE (2024)
Kirsten H. Benidickson, Lee Marie Raytek,Gordon J. Hoover,Edward J. Flaherty,Barry J. Shelp,Wayne A. Snedden,William C. Plaxton
The New phytologist (2023)
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