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The basis of my career as molecular biologist was laid by work on bacteriophages fd (in Tuebingen and Yale) and lambda (Biocenter, Basel). The studies of morphogenesis of lambda led to in vitro assembly and DNA packaging of this beautiful model virus. This was early times of recombinant DNA and the possibility to make recombinant lambda DNA infectious by packaging it into its preformed capsid was most welcome. As an extension of this work hybrid plasmids containing the phage packaging site cos, later called cosmids were developed. These allowed the cloning of large fragments of DNA and libraries of genomic DNA of many organisms were produced all over the world. However, the most interesting aspect is that of unintended, serendipitous findings applicable for unforeseen uses.
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Virus Genesno. 3 (2011): 445-453
Karen-Beth G Scholthof,Scott Adkins,Henryk Czosnek, Peter Palukaitis,Emmanuel Jacquot,Thomas Hohn,Barbara Hohn,Keith Saunders, Thierry Candresse,Paul Ahlquist,Cynthia Hemenway,Gary D Foster
The Plant Cellno. 9 (2009): 2700-2714
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