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Brodsky's research focuses on collagen, an extracellular matrix component critical for tissue structure, mechanical properties, cell adhesion and receptor mediated cell signaling. She characterizes structural features of collagen using model peptides and a recently developed recombinant bacterial collagen. The recombinant molecules serve as an excellent model system for defining collagen binding sites and the effects of collagen mutations, while the peptides allow definition of high resolution features at biologically important sites. Research is currently underway to clarify the pathway from human collagen mutations to hereditary bone disorders, kidney disease, and vascular pathology. Studies are being initiated to utilize the recombinant collagen system as a scaffold to promote bone generation by human stem cells and for the development of biomaterials.
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Papers共 125 篇Author StatisticsCo-AuthorSimilar Experts
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The Journal of biological chemistryno. 2 (2023): 102799
Collagenpp.95-112, (2018)
FIBROUS PROTEINS: STRUCTURES AND MECHANISMS (2017): 601-629
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