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The Osborne laboratory focuses on the differentiation and function of mature CD4+ lymphocytes. In particular, we are interested in the role of Notch proteins in CD4+ maturation and function. Over the past several years, we have demonstrated that Notch plays a critical role in the differentiation of the T-helper 1 (Th1) and T-helper17 (Th17) subsets of T cells. Both Th1 and Th17 cells have been implicated in several diseases including experimental autoimmune encephalomyelitis (EAE), a mouse model of Multiple Sclerosis. Using gamma-secretase inhibitors (GSIs), compounds that block the activation of Notch, we have found that we can block the development of EAE in mice, suggesting that GSIs may be a possible therapeutic for the treatment of MS. Our current studies are focused on determining how Notch signaling influences the development of EAE as well as determining which Notch family member is important in the development of disease. In mammals, there are four Notch family members and it is unclear which Notch family member is most important in driving EAE.
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论文共 143 篇作者统计合作学者相似作者
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Olga Kalinina,Lisa M. Minter,Anne I. Sperling,Maile K. Hollinger, Phong Le,Barbara A. Osborne, Shubin Zhang,Patrick Stiff, Katherine L. Knight
TRANSPLANTATION AND CELLULAR THERAPYno. 1 (2024): 79.e1-79.e10
Transplantation and cellular therapy (2023)
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Frontiers in immunology (2023): 1244159
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Rosa A. Sierra, Jimena Trillo-Tinoco, Eslam Mohamed, Lolie Yu, Bhagelu R. Achyut,Ali Arbab,Jennifer W. Bradford,Barbara A. Osborne,Lucio Miele, Paulo C. Rodriguez
crossref(2023)
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