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Dr. Sis studies inflammation and fibrosis of the kidney and liver. She described endothelial gene expression profiles in kidney transplant biopsies from patients with antibody-mediated rejection (ABMR). By these molecular studies, she discovered a new type of rejection (C4d-negative ABMR) and uncovered that many patients with ABMR remain under-diagnosed and do not receive timely treatments. These findings led to a major change in the international Banff classification to include C4d-negative ABMR as a distinct diagnostic category. At present, her laboratory is working on two research themes; 1. Multicenter studies for developing a clinical molecular test for precision diagnosis of ABMR in standard-of-care paraffin-embedded biopsy tissues with an aim to improve accurate diagnosis and better guide rejection treatments (CIHR, UHF, CNTRP, KFOC-funded); 2. Describing a multigene signature for progressive liver fibrosis, which is shared by common chronic liver diseases in humans. The gene signature findings will provide new insights into chronic liver disease progression in humans and produce an early dynamic surrogate (biomarker test) for predicting advanced liver fibrosis (UHF, ROTRF-funded).
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Bloodno. 21 (2020): 1833-1846
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B Afzali, E Chapman, M Racapé,B Adam, P Bruneval,F Gil,D Kim,L Hidalgo,P Campbell,B Sis,J P Duong Van Huyen,M Mengel
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