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个人简介
Dr Joanna Bacon: I have twenty years of experience working in TB research at Porton-Down. I have embedded basic research questions into a translational framework of research and I am PI for a team that has built its reputation on collaborative research. My research focuses on gaining a deeper understanding of the effects of growing M. tuberculosis under host-like conditions in a variety of laboratory models on bacterial physiology/biochemistry, gene expression, pathogenicity, drug susceptibility, and host-pathogen interactions. These models allow for more in-depth studies on the mechanisms of antimicrobial resistance in Mycobacterium tuberculosis and the evaluation of new drugs for the treatment of TB. My fermentation expertise and the high containment chemostat facilities I have built-up are unique in the field of TB drug research. Chemostats are the only culture-systems that are applicable to addressing growth-rate-related research questions. I have made a unique contribution to the field in the understanding of drug responses under different growth rates, by combining chemostat culture with transcriptomic analyses, and the development of tools for measuring mutation rates (Jenkins et al., 2009, Jeeves et al., 2015, Ayabina et al., 2016, & Pullan et al., 2016, Hendon-Dunn et al., 2019). The miniaturisation of our models has led to further, more rapid screening approaches that complement the use of fermenter models (Mosaei et al., 2018, Picconi et al., 2019 & Kanvatirth et al., 2019). The value of these studies has been recognised by TB Alliance and commercial organisations (GSK, Sanofi), and plays a key role in several initiatives, including the major EU-IMI PreDICT-TB consortium and NIHR-HPRU funded Unit in Respiratory Infections.
研究兴趣
论文共 47 篇作者统计合作学者相似作者
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JOURNAL OF MEDICINAL CHEMISTRYno. 4 (2024): 2529-2548
Methods in molecular biology (Clifton, N.J.) (2024): 65-77
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Sarah M. Glenn, Brindha Gap-Gaupool, Emily Milburn,Obolbek Turapov,Marialuisa Crosatti,Jennifer Hincks, Bradley Stewart,Joanna Bacon,Sharon L. Kendall,Martin I. Voskuil,Olga Riabova,Natalia Monakhova,
biorxiv(2023)
Kenneth Barry Walker,Joanna Bacon
Vaccines for Neglected Pathogens: Strategies, Achievements and Challengespp.197-209, (2023)
Charlotte Manisty,Thomas Alexander Treibel,Melanie Jensen,Amanda Semper,George Joy, Rishi K Gupta,Teresa Cutino-Moguel,Mervyn Andiapen,Jessica Jones,Stephen Taylor,Ashley Otter,Corrina Pade,
EBioMedicine (2021): 103259-103259
Thomas Keating, Samuel Lethbridge, Stephen R. Thomas,Luke J. Alderwick, Stephen C. Taylor,Joanna Bacon
The Cell Surface (2021)
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