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Bio
Dr. Carter joined the Section of Molecular Hematology and Therapy in the Department of Leukemia in 1999. Since then, her research has been focused on understanding the regulation of apoptotic regulators and targeting antiapoptotic proteins as a strategy to induce apoptosis in myeloid leukemia. Supported by AML PO-1, Dr. Carter found that survivin and XIAP, members of inhibitors of apoptosis protein family (IAPs) are highly expressed in AML and are potential therapeutic targets for AML. She recently discovered that cIAP1, another member of IAPs is significantly higher and its antagonist SMAC is significantly lower in AML stem/progenitor cells by protein array and she is investigating the potential of targeting cIAPs by SMAC mimetics in eradicating AML stem/progenitor cells and overcoming microenvironmental protection of leukemia cells. Dr. Carter also identified recently that ARC (apoptosis repressor with caspase recruitment domain), a unique antiapoptotic protein is a strong poor prognostic marker in AML and plan to investigate its roles in AML cell growth and survival and in leukemia cells/stromal interaction.
Research Interests
Papers共 188 篇Author StatisticsCo-AuthorSimilar Experts
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Hiroki Akiyama,Ran Zhao,Lauren B. Ostermann,Ziyi Li,Matthew Tcheng, Samar J. Yazdani, Arman Moayed, Malcolm L. Pryor, Sandeep Slngh,Natalia Baran,Edward Ayoub,Yuki Nishida,
LEUKEMIA (2024)
Cancer discoveryno. 7 (2023): 1656-1677
crossref(2023)
Hiroki Akiyama,Matthew Tcheng,Priyanka Sharma,Ran Zhao,Lauren B. Ostermann, Samar Yazdani, Arman Moayed,Zdzislaw Szulc,Natalia Oleinik,Po Yee Mak,Vivian Ruvolo,Bing Z. Carter,
Bing Z. Carter, Po Yee Mak, Wenjing Tao,Qi Zhang,Vivian Ruvolo, Vinitha M. Kuruvilla, Xiangmeng Wang, Duncan H. Mak, Venkata L. Battula,Marina Konopleva,Elias J. Jabbour,Paul E. Hughes,
crossref(2023)
Bing Carter,Po Yee Mak,Wenjing Tao,Lauren B Ostermann, Yuichiro Nishida,Steffen Boettcher,Michael Andreeff
Blood cancer discoveryno. 3_Supplement (2023): A08-A08
SCIENCE ADVANCESno. 48 (2023): eadh1436-eadh1436
Chendi Xie, Hui Zhou,Dongmei Qin,Huijian Zheng,Yuanfang Tang,Wenjuan Li, Jie Zhou,Long Liu, Xinxin Yu, Hongpeng Duan,Yong Zhou,Zhifeng Li,
CELL DEATH & DISEASEno. 8 (2023)
Hiroki Akiyama,Ran Zhao,Lauren B. Ostermann,Ziyi Li,Matthew Tcheng, Samar J. Yazdani, Arman Moayed, Malcolm L. Pryor II, Sandeep Slngh,Natalia Baran,Edward Ayoub,Yuki Nishida,
Leukemiano. 4 (2023): 1-12
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