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Currently, I am a certified specialist in Internal Medicine and Nephrology, and I serve as the Director of the Kidney Institute of New Mexico. My research focuses on the molecular and cellular mechanisms of magnetic resonance imaging (MRI) contrast agents. The key concerns associated with gadolinium-based contrast agent usage are progressive systemic fibrosis, kidney injury, and fatal gadolinium encephalopathy. Gadolinium-induced systemic fibrosis is clearly linked to exposure to MRI contrast agents. However, not all patients with renal disease develop systemic fibrosis, and the underlying causes are still largely unknown.
The strong staining of fibrotic lesions for CD34 and procollagen type I led to the hypothesis that the majority of cellularity originates from circulating white blood cells derived from the bone marrow, commonly known as "fibrocytes." In my laboratory, we were the first to experimentally demonstrate that MRI contrast agents prime myeloid cells, promoting multi-organ fibrosis through the monocyte chemoattractant-1/C-C chemokine receptor 2 pathway.
Our clinical studies indicate that gadolinium is distributed throughout the body, and its retention can last for years, if not indefinitely. Furthermore, the routine use of MRI contrast agents triggers the formation of gadolinium-rich nanoparticles that become fossilized as a nano precipitate and fortified within subcellular organelles. This form of gadolinium cannot be extracted through chelation therapies.
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JOURNAL OF CLINICAL MEDICINEno. 7 (2024): 1957
Journal of the American Society of Nephrologyno. 11S (2023): 1022-1022
Brent Wagner, Karol Dokladny, G. P. Escobar,Joshua Deaguero, Ian Henderson,Tamara A. Howard,Adrian Brearley
Journal of the American Society of Nephrologyno. 11S (2023): 795-795
Journal of the American Society of Nephrologyno. 11S (2023): 312-313
Joshua DeAguero,Tamara Howard,Donna Kusewitt,Adrian Brearley,Abdul-Mehdi Ali,James H. Degnan, Stephen Jett,John Watt,G. Patricia Escobar, Karol Dokladny,Brent Wagner
Kidney360no. 4 (2023): e555-e561
Journal of the American Society of Nephrologyno. 11S (2022): 290-290
Brent Wagner, G. P. Escobar,Joshua Deaguero, Karol Dokladny,Tamara A. Howard, James H. Degnan,John D. Watt,Adrian Brearley
Journal of the American Society of Nephrologyno. 11S (2022): 75-75
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