基本信息
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个人简介
My work is highly collaborative and international and concerns the interaction of Chemistry with Biomedical Science: the design, synthesis and biological evaluation of active organic molecules at the Chemistry & Biology interface aimed at dissection of fundamental mechanisms; and drug design at the Chemistry & Medicine interface to move translationally from ‘concept to clinic’. The two main research themes are:
The Chemistry of Cell Signalling: In this Chemical Biology area a unifying theme concerns cellular signalling – the chemistry of signal transduction, particularly involving “second messengers” signalling through intracellular calcium, as well as molecules involved in endocrine signalling and its modulation in oncology and endocrinology. My group is a leader internationally in exploring signalling pathways involving inositol polyphosphates and adenine nucleotides using synthetic tools. Synthetic chemistry for structure-based design is underpinned by biochemical assays, protein crystallography and in silico computational modelling.
The Chemistry of Cell Signalling: In this Chemical Biology area a unifying theme concerns cellular signalling – the chemistry of signal transduction, particularly involving “second messengers” signalling through intracellular calcium, as well as molecules involved in endocrine signalling and its modulation in oncology and endocrinology. My group is a leader internationally in exploring signalling pathways involving inositol polyphosphates and adenine nucleotides using synthetic tools. Synthetic chemistry for structure-based design is underpinned by biochemical assays, protein crystallography and in silico computational modelling.
研究兴趣
论文共 671 篇作者统计合作学者相似作者
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Lin Fu, Jimin Du,David Furkert,Megan L Shipton, Xiaoqi Liu, Tim Aguirre,Alfred C Chin,Andrew M Riley,Barry V L Potter,Dorothea Fiedler,Xu Zhang,Yi Zhu,
Cardiovascular research (2024)
Journal of medical pharmaceutical and allied sciencesno. 5 (2023): 6025-6037
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Chemistry (Weinheim an der Bergstrasse, Germany)no. 67 (2023): e202302426-e202302426
Mariana Sacerdoti,Lissy Z F Gross,Andrew M Riley, Karin Zehnder,Abhijeet Ghode,Sebastián Klinke,Ganesh Srinivasan Anand, Kristina Paris,Angelika Winkel,Amanda K Herbrand, H Yasmin Godage,Gyles E Cozier,
Science signalingno. 789 (2023)
引用2浏览0WOSSCIENCE引用
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Tania Maffucci,Enza Piccolo, Albana Cumashi,Manuela Iezzi,Andrew M. Riley,Adolfo Saiardi, H. Yasmin Godage,Cosmo Rossi,Massimo Broggini,Stefano Iacobelli,Barry V.L. Potter, Paolo Innocenti,
crossref(2023)
Ylana Adami Franco, Manoel Oliveira de Moraes Jr,Larissa A. C. Carvalho,Wolfgang Dohle,Renaira Oliveira da Silva,Isabella Harumi Yonehara Noma,Keli Lima,Barry V. L. Potter,Joao A. Machado-Neto,Silvya Stuchi Maria-Engler
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 14 (2023): 11314-11314
Megan L Shipton, Fathima A Jamion,Simon Wheeler,Andrew M Riley,Felix Plasser,Barry V L Potter,Stephen J Butler
Chemical scienceno. 19 (2023): 4979-4985
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Leon Hosang, Anke Löhndorf,Wolfgang Dohle,Anette Rosche,Stephen Marry,Björn-Philipp Diercks,Lukas C. Müller-Kirschbaum, Lioba T. Flügel,Barry V.L. Potter,Francesca Odoardi,Andreas H. Guse,Alexander Flügel
Biochimica et Biophysica Acta (BBA) - Molecular Cell Researchno. 6 (2023): 119485-119485
Tania Maffucci,Enza Piccolo, Albana Cumashi,Manuela Iezzi,Andrew M. Riley,Adolfo Saiardi, H. Yasmin Godage,Cosmo Rossi,Massimo Broggini,Stefano Iacobelli,Barry V.L. Potter, Paolo Innocenti,
crossref(2023)
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