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Bio
Research Areas: Cell biology and molecular biology of protozoan parasites, Cryptosporidium
We study the cell and molecular biology of parasites and how they interact with their mammalian host.
In recent years we have focused on the apicomplexan Cryptosporidium, a distant cousin to the parasite that cause malaria. Cryptosporidium is an important pathogen for which neither prophylaxis nor effective treatment are available. Cryptosporidium was first recognized in the 1980s as an AIDS-defining opportunistic infection, however, immunocompetent individuals are susceptible, and today Cryptosporidium accounts for 50% of all U.S. waterborne disease outbreaks.
Most recently, Cryptosporidium was identified as a leading cause of diarrheal disease and death in infants. Beyond acute disease, asymptomatic cryptosporidiosis causes stunting and environmental enteropathy with lasting impact on the development and health of children. Malnutrition and cryptosporidiosis are intimately linked. Cryptosporidium has long been difficult to study, but a series of recent advances has made the organism and the disease tractable. We developed genetic manipulation of the parasite and mouse infection models which has opened this important pathogen to sophisticated mechanistic studies.
Currently our research is exploring three areas of Cryptosporidium biology: 1) how does the parasite invade and manipulate the intestinal epithelial cells in which it develops, 2) how does the sexual part of the parasite’s lifecycle unfold and 3) how does the host immune system recognize and restrict Cryptosporidium infection?
Trainees in the lab use a broad range of modern approaches including single cell sequencing, super-resolution and live-cell microscopy, genetic engineering, flow cytometry, cryo-electron tomography and a variety of cell, organoid and animal model systems.
We study the cell and molecular biology of parasites and how they interact with their mammalian host.
In recent years we have focused on the apicomplexan Cryptosporidium, a distant cousin to the parasite that cause malaria. Cryptosporidium is an important pathogen for which neither prophylaxis nor effective treatment are available. Cryptosporidium was first recognized in the 1980s as an AIDS-defining opportunistic infection, however, immunocompetent individuals are susceptible, and today Cryptosporidium accounts for 50% of all U.S. waterborne disease outbreaks.
Most recently, Cryptosporidium was identified as a leading cause of diarrheal disease and death in infants. Beyond acute disease, asymptomatic cryptosporidiosis causes stunting and environmental enteropathy with lasting impact on the development and health of children. Malnutrition and cryptosporidiosis are intimately linked. Cryptosporidium has long been difficult to study, but a series of recent advances has made the organism and the disease tractable. We developed genetic manipulation of the parasite and mouse infection models which has opened this important pathogen to sophisticated mechanistic studies.
Currently our research is exploring three areas of Cryptosporidium biology: 1) how does the parasite invade and manipulate the intestinal epithelial cells in which it develops, 2) how does the sexual part of the parasite’s lifecycle unfold and 3) how does the host immune system recognize and restrict Cryptosporidium infection?
Trainees in the lab use a broad range of modern approaches including single cell sequencing, super-resolution and live-cell microscopy, genetic engineering, flow cytometry, cryo-electron tomography and a variety of cell, organoid and animal model systems.
Research Interests
Papers共 221 篇Author StatisticsCo-AuthorSimilar Experts
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mBiono. 8 (2024): e0172024-e0172024
Natureno. 8015 (2024): 174-180
The Journal of experimental medicineno. 7 (2024)
PLoS pathogensno. 5 (2024): e1011820-e1011820
Nature communicationsno. 1 (2024): 379-379
Matthew Martinez,Shrawan Kumar Mageswaran,Amandine Guérin,William David Chen, Cameron Parker Thompson, Sabine Chavin,Dominique Soldati-Favre,Boris Striepen,Yi-Wei Chang
mBiono. 2 (2023): e0326122-e0326122
JOURNAL OF IMMUNOLOGYno. 1 (2023)
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Author Statistics
#Papers: 222
#Citation: 12818
H-Index: 60
G-Index: 109
Sociability: 7
Diversity: 3
Activity: 82
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