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Bio
My strength as a scientist is based on my longstanding investigations of the programming of adult chronic diseases by early exposure to challenges, particularly of cardiovascular and kidney diseases, and especially in the context of developmental exposure to nutritional excess and environmental toxicants. By developing projects with health structures (University Hospital Policlinico of Modena, Italy, CHU Lyon, CHU Nice, France, and CHUV Lausanne), research laboratories (INSERM, France), and universities (Lyon, Nice, Dijon; France and UNIL; Lausanne) my works led to significant highlights in the DOHaD field. My works 1) showed the existence of developmental windows of sensitivity when exposure to endocrine-disrupting chemicals and overnutrition leads to long-term heart and kidney alterations, 2) identified microRNAs, DNA methylation, and histone methylation as underlying mechanisms in the long-term pathogenesis. After being recruited in 2014 at the CHUV, in Lausanne, I participated in the setting of the DOHaD laboratory. Willing to transmit, deepen and develop knowledge in the field of the developmental origin of health and disease, through research and teaching, I developed an independent research axe to understand the programming of cardiovascular and kidney diseases induced by challenges during early life such as maternal obesity and exposure to toxicants. As a significant advance in the field, I identified microRNAs and their biogenesis as key targets, and as potential biomarkers of diseases.
Research Interests
Papers共 38 篇Author StatisticsCo-AuthorSimilar Experts
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American Journal of Obstetrics and Gynecologyno. 1 (2024): S453
Cassandra Tabasso, Marie-Pauline Frossard, Camille Ducret,Hassib Chehade,Claire Mauduit,Mohamed Benahmed, Umberto Simeoni,Benazir Siddeek
Christian Juvet,Benazir Siddeek,Catherine Yzydorczyk,Catherine Vergely,Katya Nardou, Jean-Baptiste Armengaud,Mohamed Benahmed, Umberto Simeoni,Francois Cachat,Hassib Chehade
Catherine Yzydorczyk,Na Li,Eve Rigal,Hassib Chehade,Dolores Mosig,Jean Baptiste Armengaud, Thibaud Rolle, Anithan Krishnasamy, Eulalia Orozco,Benazir Siddeek,Christian Juvet,Catherine Vergely,
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