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个人简介
A unifying general theme is centered around cellular signalling processes and concerns both entities involved in endocrine signalling and its modulation in oncology and endocrinology, as well as the chemistry of signal transduction processes in general, but particularly those involving signalling through the elevation of Ca2+ by so-called "second messengers".
The work is characterised by a unifying focus to exploit chemical principles for intervention in Biology and Medicine, particularly stereochemistry. We aim to understand and exploit cell signalling processes in their broadest sense and to demonstrate the power of chemical synthesis and chirality for illuminating fundamental biology and for therapeutic intervention in medicine. Synthetic chemistry, particularly for bio-phosphates, nucleotides, second messengers and steroids is underpinned by biochemical assays, protein crystallography and by in silico computational design. We hope to uncover basic mechanisms, define new drug targets, design tailored synthetic drug candidates and make a therapeutic difference in areas of unmet medical need, particularly in cancer.
The work is characterised by a unifying focus to exploit chemical principles for intervention in Biology and Medicine, particularly stereochemistry. We aim to understand and exploit cell signalling processes in their broadest sense and to demonstrate the power of chemical synthesis and chirality for illuminating fundamental biology and for therapeutic intervention in medicine. Synthetic chemistry, particularly for bio-phosphates, nucleotides, second messengers and steroids is underpinned by biochemical assays, protein crystallography and by in silico computational design. We hope to uncover basic mechanisms, define new drug targets, design tailored synthetic drug candidates and make a therapeutic difference in areas of unmet medical need, particularly in cancer.
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论文共 753 篇作者统计合作学者相似作者
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Lin Fu, Jimin Du,David Furkert,Megan L. Shipton, Xiaoqi Liu,Tim Aguirre,Alfred C. Chin,Andrew M. Riley,Barry V. L. Potter,Dorothea Fiedler,Xu Zhang,Yi Zhu,
CARDIOVASCULAR RESEARCHno. 8 (2024): 954-970
María Ángeles Márquez-Moñino, Raquel Ortega-García,Hayley Whitfield,Andrew M. Riley,Lourdes Infantes, Shane W. Garrett,Megan L. Shipton,Charles A. Brearley,Barry V. L. Potter,Beatriz González
Nature Communicationsno. 1 (2024): 1-16
Bioorganic & medicinal chemistry (2024): 117645-117645
Journal of medical pharmaceutical and allied sciencesno. 5 (2023): 6025-6037
Chemistry (Weinheim an der Bergstrasse, Germany)no. 67 (2023): e202302426-e202302426
Mariana Sacerdoti,Lissy Z F Gross,Andrew M Riley, Karin Zehnder,Abhijeet Ghode,Sebastián Klinke,Ganesh Srinivasan Anand, Kristina Paris,Angelika Winkel,Amanda K Herbrand,H Yasmin Godage,Gyles E Cozier,
Science signalingno. 789 (2023)
crossref(2023)
Megan L Shipton, Fathima A Jamion,Simon Wheeler,Andrew M Riley,Felix Plasser,Barry V L Potter,Stephen J Butler
Chemical scienceno. 19 (2023): 4979-4985
Leon Hosang, Anke Löhndorf,Wolfgang Dohle,Anette Rosche,Stephen Marry,Björn-Philipp Diercks,Lukas C. Müller-Kirschbaum, Lioba T. Flügel,Barry V.L. Potter,Francesca Odoardi,Andreas H. Guse,Alexander Flügel
Biochimica et Biophysica Acta (BBA) - Molecular Cell Researchno. 6 (2023): 119485-119485
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