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Bio
We use microchip techniques for live cell imaging and screening to characterize immune response at the single cell level. T cell and natural killer (NK) cells have remarkable abilities to mediate targeted attack against virus-infected or malignant cells. In adoptive cell therapy these qualities are used to treat primary malignancies, life-threatening virus infections or leukemic relapses after allogeneic hematopoietic stem cell transplantation. Although this therapy has shown promising results we have only a remote understanding of how to utilize T and NK cells to their full potential. A major challenge is to select and prepare cells that mediate anti-tumor effects without causing life-threatening side effects such as graft versus host disease. By better understanding of how populations of NK cells and T cells are built up by individual cells with varying capacity to respond to stimuli we will be able to improve current methods for immunotherapy.
Research Interests
Papers共 151 篇Author StatisticsCo-AuthorSimilar Experts
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Faisal Al Agrafi,Ahmed Gaballa,Paula Hahn,Lucas C. M. Arruda, Adrian C. Jaramillo, Maartje Witsen,Sören Lehmann,Björn Önfelt,Michael Uhlin, Arwen Stikvoort
OncoImmunologyno. 1 (2024)
Faisal Al Agrafi,Ahmed Gaballa,Paula Hahn,Lucas C M Arruda, Adrian C Jaramillo, Maartje Witsen,Sören Lehmann,Björn Önfelt,Michael Uhlin, Arwen Stikvoort
Oncoimmunologyno. 1 (2024): 2379063-2379063
Yuanyuan You,Josefine Dunst, Kewei Ye,Patrick A Sandoz,Annika Reinhardt,Inga Sandrock, Natalia R Comet, Rupak Dey Sarkar,Emily Yang,Estelle Duprez,Judith Agudo,Brian D Brown,
Nature immunologyno. 8 (2024): 1367-1382
biorxiv(2024)
Quirin Hammer,Karlo Perica,Rina M. Mbofung,Hanna van Ooijen,Karen E. Martin,Pouria Momayyezi, Erika Varady,Yijia Pan,Mark Jelcic,Brian Groff,Ramzey Abujarour, Silje Z. Krokeide,
CANCER RESEARCHno. 7 (2023)
Research Square (Research Square) (2023)
CANCER RESEARCHno. 7 (2023)
Cancer Researchno. 7_Supplement (2023): 2950-2950
Blood advancesno. 16 (2023): 4492-4504
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Author Statistics
#Papers: 154
#Citation: 5828
H-Index: 39
G-Index: 74
Sociability: 7
Diversity: 0
Activity: 1
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