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Here he developed his interests in malaria and epidemic meningitis, both infections whose epidemiology is strongly influenced by the climate of the African Sahel and sub-Sahel. During his time in Zaria, he conducted some of the first trials of meningococcal polysaccharide vaccines and demonstrated the ability of a single injection of a long-acting chloramphenicol preparation to treat cases of meningococcal meningitis successfully during epidemics when clinical facilities could be overwhelmed.
He and his colleagues showed that because of the seasonal nature on malaria transmission in The Gambia and other countries of the African Sahel and sub-Sahel, administering antimalarial drugs to young children prophylactically during just a few months of the year could reduce mortality and morbidity in young children. Members of the malaria team also demonstrated the efficacy of intravenous artesunate in children with severe malaria and undertook one of the first trials of artemisinin combination therapy including the first trial of artemether-lumefantrine, now the most widely used treatment for malaria in Africa.
He and his colleagues showed that because of the seasonal nature on malaria transmission in The Gambia and other countries of the African Sahel and sub-Sahel, administering antimalarial drugs to young children prophylactically during just a few months of the year could reduce mortality and morbidity in young children. Members of the malaria team also demonstrated the efficacy of intravenous artesunate in children with severe malaria and undertook one of the first trials of artemisinin combination therapy including the first trial of artemether-lumefantrine, now the most widely used treatment for malaria in Africa.
Research Interests
Papers共 756 篇Author StatisticsCo-AuthorSimilar Experts
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LANCET INFECTIOUS DISEASESno. 1 (2024): 75-86
LANCET GLOBAL HEALTHno. 1 (2024): E33-E44
Anthony Mansaray, Mahmood Bangura,Deborah Watson-Jones,Brian Greenwood, Rose Burns,Shelley Susan Lees, Farba Faye,Bailah Leigh,Luisa Enria
GLOBAL PUBLIC HEALTHno. 1 (2024): 2334887-2334887
PLOS NEGLECTED TROPICAL DISEASESno. 4 (2024): e0011500-e0011500
Lancet (London, England)no. 10426 (2024): 533-544
Trialsno. 1 (2024): 1-15
VACCINEno. 10 (2024): 2680-2686
The Lancet. Infectious diseasesno. 1 (2024): 75-86
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