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个人简介
The basic and clinical research activities of the Freeman Laboratory focus on the eukaryotic cell production, reactions and signal transduction properties of oxidizing and free radical inflammatory mediators (e.g., superoxide, hydrogen peroxide, nitric oxide (NO), peroxynitrite, nitrogen dioxide, oxidized/nitrated lipids). In particular, we are interested in the action of these species as both redox signaling mediators under basal conditions and as pathogenic agents in inflammatory diseases. Our observations regarding O2 and NO-derived reactive species have lent new insight into redox-dependent cell signaling and have revealed new therapeutic strategies for treating acute inflammation, metabolic syndrome, respiratory disorders and cardiovascular diseases.
In the late 1980s, his group studied the cellular and subcellular organelle production of superoxide and hydrogen peroxide. Following the landmark description of endothelial-derived relaxing factor (EDRF) as the free radical NO, the Freeman laboratory pioneered the concept that the inflammatory and signal transduction mediator NO displays unique redox signaling actions following reaction with superoxide, oxidizing fatty acids and heme peroxidases. The “oxidative inactivation” of NO is a kinetically fast reaction, yielding “reactive nitrogen species” as products. This array of reactions of O2-derived species with NO can serve to both impair and transduce NO signaling via non-cGMP dependent mechanisms.
研究兴趣
论文共 550 篇作者统计合作学者相似作者
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Marion Mueller,Torben Schubert, Cornelius Welke, Tina Johanna Schulz,Thomas Patschkowski, Tibor Maske, Luisa Andrea Lengenfelder, Lucia Landwehrjohann, Elfi Donhauser, Elisa Theres Vogt, Bernd Stratmann, Jurek Hense,
biorxiv(2024)
Adolf Koudelka, Gregory J Buchan,Veronika Cechova, James P O'Brien,Heng Liu,Steven R Woodcock,Steven J Mullett,Cheng Zhang,Bruce A Freeman, Stacy L Gelhaus
bioRxiv : the preprint server for biology (2024)
Journal of the Acoustical Society of Americano. 3_supplement (2023): A102-A102
Lisa Hong,Dennis C Braden, Yaoning Zhao,John J Skoko,Fei Chang,Steven R Woodcock,Crystall Uvalle, Allison Casey,Katherine Wood,Sonia R Salvatore,Alparslan Asan,Trey Harkness,
Free Radical Biology and Medicine (2023): S3-S3
Fabliha A. Chowdhury, Nicole Colussi, Malini Sharma,Katherine C. Wood,Julia Z. Xu,Bruce A. Freeman,Francisco J. Schopfer,Adam C. Straub
Dennis Braden, Alp Asan,John Skoko,Bruce Freeman,Francisco Schopfer,Thomas Conrads, Ishu Saini,Caroline Kisker,Carola Neumann
Free Radical Biology and Medicine (2023): S100-S100
Victoria Heinrich,Crystal Uvalle,Michelle Manni, Sri Ramya Donepudi, Marigny Normann, Erica Fong, Steve Mullett,Bruce Freeman,Stacy Gelhaus
Free Radical Biology and Medicine (2023): S87-S87
Victoria A Heinrich,Crystal Uvalle,Michelle L Manni,Kelvin Li,Steven J Mullett, Sri Ramya Donepudi, Jason Clader,Adam Fitch,Madeline Ellgass,Veronika Cechova,Shulin Qin,Fernando Holguin,
Frontiers in microbiomes (2023)
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