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Bryan Cullen’s interests have historically revolved around the use of viruses as genetic tools to understand aspects of the biology of the eukaryotic cell, focusing particularly on RNA-sequence mediated gene regulation. Currently, his laboratory is studying the biogenesis and function of virus-encoded microRNAs, and also the use of CRISPR/Cas-based gene editing technology as a tool to investigate and inhibit the replication of several different DNA viruses. Another important research interest is focused on identifying and mapping post-transcriptional modifications of viral mRNAs and determining how these “epitranscriptomic” modifications affect viral replication and pathogenicity.
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Viral Regulatory Structures and their Degeneracypp.85-100, (2018)
CHEMICAL & ENGINEERING NEWSno. 30 (2007): 29-29
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