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个人简介
Graduate Degree: M.Sc., PhD in Molecular Biology
Graduate Degree Institution: Institute of Molecular Biology, Bulgarian Academy of Sciences
Undergraduate Institution: Sofia State University, Sofia, Bulgaria
Research interests: Our long standing interests involve the molecular mechanisms mediating the adaptive (and maladaptive) responses to different types of stress as relates to altered expression of neurotransmitter genes in the central and peripheral nervous systems. Current research projects are aimed to test the hypothesis that early pre/postnatal gut colonization can augment the maturation and function of sympathoadrenal responses to classic stressors during development, providing an evolutionarily preserved survival advantage in neonates (rodents as well as humans). Preliminary results provided a proof of concept that counter-regulatory responses to acute insulin induced hypoglycemia and adrenal catecholamine homeostasis are affected in mice lacking microbiome (germ free). Our alternative strategy is to employ antibiotics-induced gut dysbiosis combined with/or without concurrent mono/ whole gut bacterial recolonization or supplementation with bacterial metabolites. That would make the animal model more relevant to the human situation (poor neurodevelopmental outcomes following antibiotic therapy in pregnant moms and pre-term/term babies in early postnatal life). In addition, our novel approach is to study gut-microbiota-brain interface at individual synapse - the excitatory preganglionic-adrenal chromaffin cell synapse, the final step in the multi-neuronal signaling pathway(s) that results in release of epinephrine. It represents an easily accessible peripheral model of central catecholaminergic neurons and allows for manipulation of transsynaptic and hormonal signaling that may be influenced by chemical messages arising from acquired microbial symbionts at birth, as well as a reliable and robust outcome measure.
研究兴趣
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Biology of Sex Differencesno. 1 (2024): 1-23
NEUROBIOLOGY OF STRESS (2023): 100533-100533
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#Papers: 75
#Citation: 2290
H-Index: 26
G-Index: 46
Sociability: 5
Diversity: 3
Activity: 12
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