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My research focuses on fundamental aspects of RNA biology in Archaea. I have an extensive experience in RNA and protein biochemistry, and have developed an innovative area of research involving the identification and characterization of non-coding RNAs, RNases and helicases in Archaea. Actually, I supervise the “RNA biology of Archaea” team at the MCD-CBI. The challenge of our project, in close collaboration with local, national and international partners, is to identify the archaeal machineries implicated in RNA processing, turnover and quality control that are at the centre of gene expression regulation in Euryarchaea. We obtained the first hints towards identifying novel archaeal ribonucleases in our published systematic phylogenomic and experimental work characterizing aCPSF1 and aRNase J as highly conserved β-CASP ribonucleases in Archaea. We tackle the biological function of archaeal β-CASP RNases and associated RNA helicases and their interplay in RNA metabolism of the archaeal cell. We believe that our work will provide knowledge that should prove to be milestones in the fields of RNA metabolism and molecular biology of Archaea, the third domain of life, and potentially clarify corresponding mechanisms in Eukarya and Bacteria. In addition, it should enlighten us on specific molecular processes that allow the archaeal cells to sustain an extremophile lifestyle.
Research Interests
Papers共 36 篇Author StatisticsCo-AuthorSimilar Experts
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Zackie Aktary,Anne Cucchiarini,Guglielmo Vesco, Dorian Noury, Thomas Jourdain,Daniela Verga,Pierre Mahou,Nicolas Olivier,Natalia Valková,Otilia Porubiaková,Václav Brázda,Marie Bouvier,
biorxiv(2024)
NAR genomics and bioinformaticsno. 1 (2024): lqae026-lqae026
Béatrice Clouet-d’Orval, Bin Tian
semanticscholar(2021)
Mirna Hajj, Samar El-Hamaoui,Manon Batista,Marie Bouvier,Ziad Abdel-Razzak,Béatrice Clouet d'Orval,Hala Chamieh
Helicases from All Domains of Lifepp.1-18, (2019)
Mirna Hajj, Samar El-Hamaoui,Manon Batista,Marie Bouvier,Ziad Abdel-Razzak,Beatrice Clouet D'Orval,Hala Chamieh
HELICASES FROM ALL DOMAINS OF LIFE (2019)
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