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个人简介
As a devoted researcher specializing in stem cells and neuroscience, my primary objective is to expand our understanding of neurological disorders by utilizing induced pluripotent stem cells (iPSCs). With a wealth of experience spanning over ten years, I adeptly employ a diverse array of cutting-edge methodologies, including electrophysiology, imaging, molecular biology, and genetics, to delve into the intricate realm of brain disorders. My doctoral investigations revolved around the enigmatic realm of sleep bruxism (SB), wherein I harnessed the potential of iPSC-derived neurons to unravel the intricate complexities underlying this phenomenon. This immersive experience served as a catalyst, igniting an unwavering passion within me to unravel the multifaceted nature of neurological disorders and craft groundbreaking therapeutic strategies at the forefront of innovation.
During my Ph.D. research, I had the opportunity to contribute as a co-author to a groundbreaking study titled "In vitro monitoring of HTR2A-positive neurons derived from human iPSCs" (Nakai K, 2021, Scientific Reports). This research aimed to shed light on the intricate pathophysiological mechanisms underlying various neurological disorders linked to genetic variations of the HTR2A gene. In parallel, I conducted a comprehensive investigation into the disease modeling of HTR2A variant-related sleep bruxism (SB) using iPSC-derived neurons (Sarkar AK, 2022, Stem Cell Research). Notably, my findings revealed hyperexcitability in SB iPSC-derived neurons, unraveling aberrant neural patterns and molecular characteristics associated with this condition. By integrating the study of genetic variations, particularly the HTR2A variant, I gained valuable insights into its impact on neuronal activity and identified novel targets for potential therapeutic interventions. These significant strides in understanding the pathophysiological mechanisms of SB have paved the way for future advancements in intervention strategies.
Motivated by my drive to further contribute to the field of neurological disorders, I sought a postdoctoral position that would allow me to expand my expertise and make a tangible impact. It is through this pursuit that I joined the amyotrophic lateral sclerosis (ALS) project at Cincinnati Children's Hospital Medical Center (CCHMC), where I have the privilege of working with a team of esteemed researchers dedicated to unraveling the underlying mechanisms of this devastating disease.
In my first year as a postdoctoral fellow, I had the opportunity to contribute to a transformative project that aimed to decipher the intricate neuron-glial crosstalk mediated by microRNAs in Alzheimer's disease (AD) (Zhou LT, 2023, Science Advances). Our collaborative effort involved utilizing AD transgenic mouse models and iPSCs to explore the potential of microRNA-based therapeutic approaches. This research has the potential to revolutionize our understanding of neurodegenerative diseases and pave the way for groundbreaking interventions in AD.
Building upon the knowledge and skills acquired during my Ph.D. research, I am now channeling my expertise towards unraveling the mysteries of ALS using iPSCs. By employing a range of approaches such as electrophysiology, imaging, molecular biology, and genetics, I am investigating the cellular and molecular mechanisms underlying ALS pathogenesis. Through interdisciplinary collaborations and a comprehensive approach, I aim to identify key therapeutic targets and contribute to the development of effective treatments for ALS.
Throughout my research journey, I have actively engaged in scientific collaborations, presenting my findings at national and international conferences to exchange knowledge and receive valuable feedback from fellow researchers. Additionally, I am committed to mentoring and guiding aspiring scientists, fostering a passion for research, and instilling a sense of scientific inquiry in the next generation.
Looking ahead, my ultimate goal is to bridge the gap between research and clinical practice by translating my findings into tangible clinical applications. By forging collaborations with experts in the field, embracing emerging technologies, and advocating for a multidisciplinary approach, I am dedicated to making a lasting impact on the lives of ALS patients and their families.
In summary, my research journey has been characterized by a relentless pursuit of understanding the intricacies of neurological disorders and developing innovative therapeutic strategies. From my Ph.D. research on SB to my current work in ALS at CCHMC, I am driven by a passion for making a meaningful impact on the lives of patients. By exploring the underlying mechanisms and identifying therapeutic targets, I aim to.
研究兴趣
论文共 7 篇作者统计合作学者相似作者
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Lan Dao, Zhen You, Lu Lu, Tianyang Xu,Avijite Kumer Sarkar, Hui Zhu, Miao Liu,Riccardo Calandrelli, George Yoshida, Pei Lin,Yifei Miao, Sarah Mierke,
Cell Stem Cellno. 6 (2024): 818-833.e11
NPJ Parkinson's diseaseno. 1 (2023): 139-10
The Journal of Japanese Society of Stomatognathic Functionno. 1 (2021): 28-29
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