基本信息
views: 55
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
This laboratory seeks to understand the molecular events that control excitation in cardiac muscle and the mechanisms by which excitation is modified by drugs. The experimental models include the isolated cardiac myocyte, the frog oocyte and mammalian cells expressing mRNA transcripts of wild-type and mutant channels. The experimental techniques include DNA and RNA manipulation, whole cell voltage clamping and the extracellular patch clamping. The current focus of the laboratory is the voltage gated sodium channel. The problems under study include:
1) The functional effects of the derangements occurring during
myocardial ischemia on channel function.
2) The mechanisms of blockade of channels by antiarrhythmic drugs.
3) The relationship between channel structure and antiarrhythmic drug
binding.
4) The development of models to describe the interaction of anti-
arrhythmic drugs with membrane channels.
1) The functional effects of the derangements occurring during
myocardial ischemia on channel function.
2) The mechanisms of blockade of channels by antiarrhythmic drugs.
3) The relationship between channel structure and antiarrhythmic drug
binding.
4) The development of models to describe the interaction of anti-
arrhythmic drugs with membrane channels.
Research Interests
Papers共 98 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Circulationno. 12 (2024): e964-e985
Yu Wang,Rashmi Chandra,Leigh Ann Samsa, Barry Gooch,Brian E Fee, J Michael Cook,Steven R Vigna,Augustus O Grant,Rodger A Liddle
mag(2009)
Cited23Views0Bibtex
23
0
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn