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Bio
Augustas Pivoriūnas graduated from Vilnius University Medical Faculty in 1998 (M.D.) and received Ph.D. (2004) in Biochemistry from the Institute of Biochemistry in Vilnius. As a holder of Marie Curie fellowship (Contract Nr: HPMT-GH-00-00130-04) he spent 2 years (2002-2004) at the Department of Medical Microbiology, Linköping University, Sweden. He joined the Department of Experimental Medicine at the Institute of Experimental and Clinical Medicine in Vilnius as research scientist in 2005. From 2010 to 2019 he served as a senior research scientist at the State Research Institute Centre for Innovative Medicine (SRICIM) in Vilnius and from 2012 he was appointed as a Head of the Department of Stem Cell Biology. From 2014 to 2020 he served as a Deputy director for Scientific Affairs at the SRICIM and from 2019 holds position of Chief research fellow.
From 2014 Augustas Pivoriūnas is the President of the Lithuanian Association of Stem Cell Researchers.
Augustas Pivoriūnas is a co-founder and shareholder of the joint stock company Exosomica.
Augustas Pivoriūnas leads an active group of scientists and PhD students and his research interests focus primarily on extracellular vesicles (EVs) derived from different types of adult stem cells and their applications in basic research and cell-based therapies. In recent years he studies neuroprotective effects of EVs derived from human dental pulp stem cells (DPSCs) using in vitro and in vivo models of neurodegenerative diseases. His group was among the first to demonstrate that EVs can rescue human dopaminergic neurons from 6-hydroxydopamine (6-OHDA)-induced apoptosis in vitro (Cytotherapy. 2015 Jul;17(7):932-9). More recently, his group together with partners from the University of Latvia demonstrated for the first time that intranasal administration of EVs derived from the DPSCs can effectively suppress 6-OHDA-induced gait impairments and normalize tyrosine hydroxylase expression in the striatum and in the substantia nigra of experimental rats (Stem Cells Transl Med. 2019 May;8(5):490-499, paper is winner of STEM CELLS Translational Medicine 's Young Investigator Award 2020). Further studies demonstrated that EVs reversed spatial learning/memory impairments caused by intra-MFB injection of 6-OHDA (Cell. Mol. Neurobiol, 2021 Apr;41(3):605-613.). These findings demonstrate that intranasal administration of EVs preserve dopaminergic neurons, can substantially improve motor and non-motor symptoms of the PD and therefore could be potentially used for the development of novel and minimally invasive therapy.
Research Interests
Papers共 51 篇Author StatisticsCo-AuthorSimilar Experts
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FUNCTIONno. 2 (2024): zqae002-zqae002
Neural regeneration researchno. 4 (2024): 709-710
The FEBS journal (2024)
Cell biology internationalno. 3 (2023): 358-368
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