基本信息
views: 6
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
A fundamental capacity of the mammalian cerebral cortex is to process information in a form conducive to encoding, storage and retrieval of memories. A general organizational principle of cortical mnemonic circuits states that these steps all require a precisely orchestrated spatio-temporal interaction among a large number of relatively uniform excitatory and a numerically fewer but richly diverse population of inhibitory and neuromodulatory circuit elements. However, a mechanistic understanding of how these circuit motifs interact during elementary steps of memory processing is lacking. Our general hypothesis is that single neurons perform complex computations by exploiting their multilayered and compartmentalized dendritic arborization. Specifically, we hypothesize that, (1) neuronal dendritic arbor constitutes a backbone for both compartmentalized input integration and plasticity, and (2) dynamic interactions between synaptic and intrinsic forms of neuronal plasticity can expand neuron’s capability to detect, store and recall various features of information.
To test these predictions, we use a variety of techniques: direct electrophysiological recordings from various compartments of neurons, simultaneous patch-clamp recordings from multiple neurons, together with two-photon imaging/photoactivation and optogenetics.
A major focus of our lab will be to understand how dynamic spatio-temporal interactions among excitatory, inhibitory and neuromodulatory inputs in different subcellular domains fundamentally enhance information processing and storage capabilities of single and small networks of neurons in the hippocampal circuit
Another aspect of our work will focus on testing the prediction that intrinsic and synaptic forms of neuronal plasticity bidirectionally interact within dendritic compartments. We also aim to reveal exact mechanisms how these different forms of neuronal plasticity are affected by inhibition and neuromodulation.
The long-term goal of our laboratory is to establish causal links between single cell computations and behavior.
To test these predictions, we use a variety of techniques: direct electrophysiological recordings from various compartments of neurons, simultaneous patch-clamp recordings from multiple neurons, together with two-photon imaging/photoactivation and optogenetics.
A major focus of our lab will be to understand how dynamic spatio-temporal interactions among excitatory, inhibitory and neuromodulatory inputs in different subcellular domains fundamentally enhance information processing and storage capabilities of single and small networks of neurons in the hippocampal circuit
Another aspect of our work will focus on testing the prediction that intrinsic and synaptic forms of neuronal plasticity bidirectionally interact within dendritic compartments. We also aim to reveal exact mechanisms how these different forms of neuronal plasticity are affected by inhibition and neuromodulation.
The long-term goal of our laboratory is to establish causal links between single cell computations and behavior.
Research Interests
Papers共 104 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
bioRxiv the preprint server for biology (2024)
Daniel M. Virga,Stevie Hamilton,Bertha Osei, Abigail Morgan,Parker Kneis,Emiliano Zamponi, Natalie J. Park,Victoria L. Hewitt,David Zhang,Kevin C. Gonzalez,Fiona M. Russell,D. Grahame Hardie,
Stephanie A. Herrlinger,Bovey Y Rao, Margaret E. Conde Paredes, Anna L. Tuttman, Haroon Arain,Erdem Varol,Joseph A. Gogos,Attila Losonczy
crossref(2024)
Zhenrui Liao,Kevin C Gonzalez, Deborah M Li, Catalina M Yang, Donald Holder, Natalie E McClain,Guofeng Zhang,Stephen W Evans,Mariya Chavarha, Jane Yi,Christopher D Makinson,Michael Z Lin,
Nature Communicationsno. 1 (2024): 1-16
Jingcheng Shi, Boaz Nutkovich,Dahlia Kushinsky,Bovey Y Rao,Stephanie A Herrlinger,Tiberiu S Mihaila,Katayun Cohen-Kashi Malina, Cliodhna K O'Toole, Margaret E Conde Paredes, Hyun Choong Yong,Erdem Varol,Attila Losonczy,
bioRxiv : the preprint server for biology (2024)
bioRxiv : the preprint server for biology (2024)
John C Bowler, George Zakka, Hyun Choong Yong,Wenke Li, Bovey Rao,Zhenrui Liao,James B Priestley,Attila Losonczy
bioRxiv : the preprint server for biology (2024)
Neuronno. 24 (2023): 4024-4039.e7
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Load More
Author Statistics
#Papers: 103
#Citation: 7671
H-Index: 37
G-Index: 72
Sociability: 6
Diversity: 2
Activity: 257
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn