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The expression of individual genes is controlled at the levels of mRNA transcription and also post-transcriptionally, by processes such as splicing, localization, modification or editing, and degradation. To gain a mechanistic understanding of these processes it is important to understand the interactions between the individual players, including both protein and nucleic acid components, at the molecular level. We have used structural approaches to tackle mechanistic questions about how protein-RNA interactions can control RNA maturation and RNA editing and how transcriptional repressors are recruited to methylated DNA. By combining structural studies with biochemical, biophysical and cell-based functional assays we can gain powerful insights into these molecular processes.
The expression of individual genes is controlled at the levels of mRNA transcription and also post-transcriptionally, by processes such as splicing, localization, modification or editing, and degradation. To gain a mechanistic understanding of these processes it is important to understand the interactions between the individual players, including both protein and nucleic acid components, at the molecular level. We have used structural approaches to tackle mechanistic questions about how protein-RNA interactions can control RNA maturation and RNA editing and how transcriptional repressors are recruited to methylated DNA. By combining structural studies with biochemical, biophysical and cell-based functional assays we can gain powerful insights into these molecular processes.
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Ansgar Zoch, Gabriela Konieczny,Tania Auchynnikava,Birgit Stallmeyer,Nadja Rotte, Madeleine Heep,Rebecca V Berrens, Martina Schito,Yuka Kabayama,Theresa Schöpp,Sabine Kliesch,Brendan Houston,
Molecular cellno. 6 (2024): 1021-1035.e11
RNA (New York, N.Y.) (2023)
Acta crystallographica. Section D, Structural biologyno. Pt 6 (2023): 449-461
Life Science Allianceno. 3 (2022): e202201588-e202201588
Molecular biology and evolutionno. 5 (2021): 1837-1846
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