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Bio
A proficient in Medicinal chemistry/ Organic chemistry/ Basic chemistry/pharmaceutical sciences with an experience of 9 years in research and academic sector. Over the years developed expertise in basic as well as applied research (medicinal/ pharmaceutical chemistry; natural product based medicinal chemistry and carbohydrate chemistry) as an assistant professor and researcher in the Natural Product Chemistry division of CSIR-Indian Institute of Integrative Medicine, (IIIM) Jammu. Have experienced in methodologies in translation research like non-infringing routes for the synthesis of APIs and synthesis of drug active metabolites using green chemistry. In natural product chemistry I have expertise in isolation of secondary metabolites from microbial and plant sources, DOS, semi-synthetic modifications, and medicinal chemistry against specific targets in cancer, diabetics, inflammation, etc. Having a pharmaceutical science educational background, a clear understanding of the subjects beyond research area has been achieved. Expertise in drug development process commencing from synthesizing, optimizing up to its detailed pharmacology. Sincere efforts for synthesizing new drug discovery targeting these vital aspects of cancer and have a good working experience with methodologies in organic chemistry has been achieved. Has published expensively in peer-reviewed journals, also published book chapters with springer and Elsevier publishers. In an academic role, mentoring doctoral research scholar (1 Ph.D.) and M. Pharm students (12 Dissertations) as well as B. Pharm students (30 dissertations). I am imparting my experience in research, mentoring and leadership skills amongst the students of Shoolini University, Solan, HP and teaching them medicinal chemistry.
EDUCATION
Ph.D. (2018) -Pharmaceutical Sciences
Indian Institute of Integrative Medicines, (CSIR), Jammu
Guru Nanak Dev University, Amritsar
Title of Thesis: ‘Diversity Oriented Synthesis of Novel Benzopyran Derivatives and Evaluation of their Pharmacological Properties’ (Registration no. 2013. PhD (BP)-01)
Supervisor: Dr. Debaraj Mukherjee, Senior scientist, IIIM, Jammu, J&K.
M. Pharmacy (Pharmaceutical Chemistry) (2012) – University of Pune (P. R No. 6920110415)
B. Pharmacy (2010) – Biju Patnaik University of Technology, Rourkela, Orissa, India (REGD. NO. 0603267012)
RESEARCH EXPERTISE
Expertise in drug development as well as in basic chemistry. This in details involves all the organic syntheses, purification by recrystallization techniques, all the chromatography methods, NMR, IR, Mass spectroscopy, etc, and its pharmacological evaluation against specific targets.
In pharmaceutical chemistry experienced in Molecular hybridization (MH) technique, used to combine two medicinally important scaffolds such as chromene (different benzopyrans /coumarins /flavones) and dihydropyrimidinone).
Utilized heterogeneous catalyst (SiW (H4W12SiO40), PMo (H3PMo12O40), SiMo (H4SiO4Mo12O36), PW (H3PW12O40)) in organic reactions.
In carbohydrate chemistry synthesis of natural molecule mimicking flavones-C-glycosides and coumarin-C-glycoside modulating traditional carbon-Ferrier rearrangement reaction altering it to one pot Mukaiyama type carbon Ferrier rearrangement reaction. I had developed a new method for the O-arylation of carbohydrates under metal-free conditions using arynes as an aryl source with my other colleagues.
In natural product chemistry, I have isolated different natural molecules such as Flavonoids, xanthones, triterpenes and seccoiridoids from the extracts of 5 different plants including Swertia Angustifolia, Pinus gerardina, etc. Different techniques were used for the isolation such as Morphological/Anatomical Analysis, TLC/HPTLC analysis, HPLC Analysis, GC Analysis, Spectroscopic Methods: NMR/MS/NIR/FT-IR. Molecular Biological Methods. Natural product isolation (various Xanthones, Oleanolic acid, beta-sitosterol, etc.) and semi-synthetic work on Swertia Angustifolia. Recently I have developed Induction of systemic acquired resistance against French bean rust by exogenously applying some natural molecules.
Applying green chemistry I have developed a novel method for the synthesis of various chromene dihydropyrimidinone (CDHPM) molecules using recyclable Fe/Al pillared clay catalyst and studied their pharmacokinetic parameters like aqueous solubility, lipophilicity, P-glycoprotein (P-gp) dependent ATPase activity, permeability, plasma protein binding, red blood cell (RBC) partitioning, metabolic stability in liver microsomes and in-vitro-in-vivo computations. Also studied ligand interaction for those compounds with LYS 218 &GLN 220of NF-kB (PDB: 1NF I) as target protein to study the interaction of DHPMs with the target protein.
Research Interests
Papers共 21 篇Author StatisticsCo-AuthorSimilar Experts
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Kaustav Mukherjee,Vivek Panwar,Deepak Kumar Jindal,Sandeep Kumar,Isha Dhamija,Deepak Kumar,Ashutosh Dash
BENTHAM SCIENCE PUBLISHERS eBookspp.235-244, (2023)
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BENTHAM SCIENCE PUBLISHERS eBookspp.17-42, (2023)
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Research Journal of Pharmacy and Technologypp.5774-5778, (2022)
Phytomedicine plusno. 2 (2021): 100024
biorxiv(2020)
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Author Statistics
#Papers: 20
#Citation: 228
H-Index: 7
G-Index: 15
Sociability: 4
Diversity: 0
Activity: 1
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