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个人简介
Our research addresses two major questions. Our uniquely multi-disciplinary research bridges from bench to bedside, subtending a wide range of techniques from molecular cell biology to single-cell/single-molecule imaging to structural biology, biophysics and chemistry.
My laboratory aspires to understand the mechanisms underlying human cancer susceptibility, in order to find innovative ways to intercept cancer early in its evolution. Genome instability, a hallmark and driver of cancer evolution, arises early in carcinogenesis, through the failure of mechanisms that normally safeguard genome integrity. We study these mechanisms to understand how their malfunction leads to cancer, and have devised powerful new technologies to translate this knowledge to clinical application for early cancer detection and treatment. One major interest is in the ‘breast cancer gene’ BRCA2, whose vital role as a genome guardian we were amongst the first to discover.
研究兴趣
论文共 33 篇作者统计合作学者相似作者
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Li Ren Kong,Komal Gupta, Andy Jialun Wu,David Perera, Roland Ivanyi-Nagy,Syed Moiz Ahmed,Tuan Zea Tan, Shawn Lu-Wen Tan, Alessandra Fuddin,Elayanambi Sundaramoorthy, Grace Shiqing Goh, Regina Tong Xin Wong,
Cell (2024)
Teresa Lai Fong Ho,May Yin Lee,Hui Chin Goh, Germaine Yi Ning Ng, Jane Jia Hui Lee,Srinivasaraghavan Kannan,Yan Ting Lim,Tianyun Zhao,Edwin Kok Hao Lim, Cheryl Zi Jin Phua,Yi Fei Lee, Rebecca Yi Xuan Lim,
Nature communicationsno. 1 (2023): 1726-18
Maryam Ghaderi Najafabadi,G. Kenneth Gray,Li Ren Kong,Komal Gupta,David Perera,Joan Brugge,Ashok Venkitaraman,Mona Shehata
bioRxiv (Cold Spring Harbor Laboratory) (2022)
biorxiv(2021)
Amy Emery,Bryn S Hardwick,Alex T Crooks,Nadia Milech,Paul M Watt, Chandan Mithra,Vikrant Kumar,Saranya Giridharan,Gayathri Sadasivam,Subashini Mathivanan, Sneha Sudhakar,Sneha Bairy,
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