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Bio
Dr. Srivastava’s research has been focused on the following two parvoviruses, the non-pathogenic adeno-associated virus (AAV), and a common human pathogen, the parvovirus B19, and the development of recombinant parvovirus vectors in human gene therapy. His laboratory has made seminal contributions to the field of parvoviruses, which include: identification of cellular co-receptors for AAV2 and AAV3 as well as parvovirus B19; elucidation of various steps involved in parvovirus trafficking in the cell and nuclear transport; identification of cellular proteins involved in the regulation of AAV DNA replication and encapsidation; development of recombinant AAV and parvovirus B19 vectors; and transgenic and knockout mouse models to study parvovirus-induced pathogenicity, and the use of parvovirus vectors for gene transfer and gene therapy. Recently, his laboratory has developed the next generation (“NextGen”) AAV vectors in which the viral capsid has been modified to achieve high-efficiency transduction at significantly reduced vector doses. More recently, his laboratory has also modified the AAV genome to develop the generation X (“GenX”) AAV vectors with which increased transgene expression can be achieved. The NextGen AAV vectors have been used by other investigators in a Phase I Clinical Trial for Leber’s Hereditary Optic Neuropathy (LHON). The NextGen and the GenX vectors have been combined in Dr. Srivastava’s laboratory to develop the optimized [“Opt”] AAV serotype vectors, and the current emphasis is on gene therapy of malignant disorders such as hepatoblastoma and hepatocellular carcinoma, and gene therapy/genome editing of genetic diseases such as hemophilia, β-thalassemia and sickle cell disease.
Research Interests
Papers共 620 篇Author StatisticsCo-AuthorSimilar Experts
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E3S Web of Conferences (2024): 01005
Swati Tyagi,Arun Srivastava
Aerobiologiano. 8 (2024): 1-15
Arun Pratap Srivastava, Priyanka Gupta,Vijilius Helena Raj, Manish Gupta,Neha Khare,Muntather Almusawi
2024 IEEE 13th International Conference on Communication Systems and Network Technologies (CSNT)pp.965-971, (2024)
Gudainiyan Jitendra, Kumar Rahul, Singh Dhiraj, Sing Durgeshwar Pratap,Shrivastava Anurag,Srivastava Arun Pratap,Khan Akhilesh Kumar
E3S Web of Conferences (2024): 01011
Human gene therapyno. 5-6 (2024): 133-134
2024 4th International Conference on Innovative Practices in Technology and Management (ICIPTM)pp.1-6, (2024)
Toxicology and Environmental Health Sciencespp.1-16, (2024)
2024 4th International Conference on Innovative Practices in Technology and Management (ICIPTM)pp.1-6, (2024)
Deepak Kumar, Himanshu Kumar,Sunil B. Ingole, Soni Kumari,Yatika Gori,Arun Pratap Srivastava,Akhilesh Kumar Khan
E3S Web of Conferences (2024): 01014
2024 4th International Conference on Innovative Practices in Technology and Management (ICIPTM)pp.1-6, (2024)
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Author Statistics
#Papers: 625
#Citation: 14771
H-Index: 63
G-Index: 106
Sociability: 7
Diversity: 4
Activity: 33
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