基本信息
浏览量:0
职业迁徙
个人简介
Research in the Laboratory of Chemical Biology (LCB), for which Dr Grollman serves as Director, focuses on the biological consequences of DNA damage with specific reference to molecular mechanisms of DNA replication, mutagenesis, and DNA repair. Research in the LCB was instrumental in establishing the mechanism of action of bleomycin and in defining an important error-avoidance pathway that protects cells against mutations resulting from miscoding effects of oxidative DNA damage. He and his collaborators established the three-dimensional structures of DNA glycosylases and DNA polymerases bound to site-specifically modified DNA, thereby correlating the molecular structure of damaged DNA with enzymatic function. Current research focuses on molecular and cellular mechanisms involved in the nephrotoxicity of the human carcinogen, aristolochic acid.
研究兴趣
论文共 345 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Thomas A. Rosenquist, Chung H. Chen,Jingshu Guo,Scott J. Walmsley,Kathleen G. Dickman, Yeong S. Pu,Robert J. Turesky,Arthur P. Grollman
CANCER SCIENCE (2023): 78-78
引用0浏览0引用
0
0
European Urologyno. 2 (2020): 209-220
引用3浏览0WOS引用
3
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn