基本信息
views: 26
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
My interests in protein structure and function, DNA dynamics, and genetic mechanisms have related primarily to the class of reactions known as site-specific recombination. More specifically, my laboratory has focused on the pathway by which the model virus bacteriophage lambda integrates its DNA into the chromosome of its cellular host, E. coli, where it is capable of residing in perpetuity. Under the appropriate conditions, such as physiological stress, this same recombination pathway precisely excises the viral DNA as a prelude to the cycle of virus growth that ultimately lyses the host cell to release a burst of infectious virus particles. High-resolution studies of this recombination pathway, in my laboratory and others, have revealed a complex reaction involving four different proteins that recognize a collection of 15 binding sites on the viral and bacterial DNA. The reaction mechanism has afforded a facile opportunity to study the formation and resolution of four-way DNA junctions, and the proteins and DNA together comprise a family of higher-order complexes whose structure, dynamics, and mechanism of function continue to challenge us.
Research Interests
Papers共 90 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Molecular microbiologyno. 5 (2024): 895-911
Gurunathan Laxmikanthan, Chen Xu,Axel F Brilot, David Warren, Lindsay Steele,Nicole Seah,Wenjun Tong,Nikolaus Grigorieff,Arthur Landy,Gregory D Van Duyne
crossref(2016)
Microbiology Spectrumno. 2 (2015)
Proceedings of the National Academy of Sciences of the United States of Americano. 34 (2014): 12372-7
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn