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Konnerth’s research focuses on mechanisms that determine activity-dependent modifications of the function and structure of neurons. These modifications, including long-term potentiation and long-term depression, occur during the development of the nervous system, but represent also an ongoing feature of neurons in adults. He studies different types of neurons in the cortex, cerebellum and hippocampus, and uses a variety of techniques, including patch-clamp recordings from neurons in brain slices and high-resolution imaging. Another major focus of his laboratory is the investigation of the mechanisms of synaptic wiring in the immature cortex and hippocampus. After observing the activity-dependent conversion of silent glutamatergic synapses into conducting ones in the developing hippocampus, he started to investigate synaptic signaling and plasticity in immature neuronal networks.
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biorxiv(2023)
Benedikt Zott, Lea Nästle,Christine Grienberger, Manuel Knauer, Felix Unger, Aylin D Keskin, Anna Feuerbach,Marc Aurel Busche,Arne Skerra,Arthur Konnerth
Research Square (Research Square) (2023)
user-62626388733dcd7b976fc01e(2020)
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